Capsules for preventing and treating exaggerative pain after anesthesia and preparation method thereof

Abstract

The invention discloses capsules for preventing and treating exaggerative pain after anesthesia and a preparation method thereof. The preparation method of the capsules is characterized by comprising the following steps: (1), extracting essential oil from red fruit fig-tree leaves, almonds, herba sarcandrae, folium eucalypti, seeds of feather cockscomb and centipeda minima coarse powder respectively by using a distillation method of water vapour, then mixing for later use after collection, and leaving dregs for later use; (2),uniformly mixing nostoc sphaeroides, serissa serissoides, dendrobe, common hogfenneI roots, smoked plum, pawpaws and the dregs obtained in the step 1, adding 10 times of water, adding water and boiling for one hour for two times, mixing decoctions and performing still standing; adding 95 percent of ethyl alcohol, which is 3-4 times of liquid, into decoction, performing still standing for 15 minutes, then carrying out centrifugation for 20 minutes in 3000 rpm / min, taking clear liquid and carrying out spray drying after concentration, and obtaining a primary material; (3), spraying essential oil obtained in the step 1 into the primary material obtained in the step 3, crashing and sieving through a 60-mesh sieve, and carrying out subpackage, so that the capsules are obtained. Clinical experiment results show that the capsules have the characteristics of good curative effect and high safety in relieving post-operation pain, and is worthy of clinical application and promotion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a capsule for preventing and treating exaggerated pain after anesthesia and a preparation method thereof. Background technique [0002] Previous animal experiments and human studies have shown that anesthesia is closely related to postoperative pain hypersensitivity, such as isoflurane 0.2%-0.3% MAC, remifentanil anesthesia, pain hypersensitivity may occur after taking naloxone antagonistic opioids, Also known as exaggerated pain. Postoperative pain hypersensitivity was associated with high expression of NMDA receptors, nitric oxide and nitric oxide synthase, and central sensitization. Animal experiments have shown that formalin-induced hyperalgesia can be suppressed by pre-administration of Celebrex, but post-medication is ineffective, but subarachnoid injection of non-selective COX inhibitors can inhibit hyperalgesia before and after the onset of hyperalgesia. How...

AI Technical Summary

Problems solved by technology

Animal experiments have shown that formalin-induced hyperalgesia can be suppressed by taking Celebrex beforehand, but the subsequent administration is ineffective, but subarachnoid injection of non-selective COX inhibitors can inhibit hyperalgesia before and after the onset of hyperalgesia