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A kind of medical composite dressing and preparation method thereof

A medical and mixed treatment technology, which is applied in the field of medical composite dressings and its preparation, can solve the problems of not being able to effectively promote the healing of chronic wounds, achieve enhanced wound healing, good antibacterial, anti-inflammatory and hemostatic effects, and good tear and tear strength Effect

Active Publication Date: 2015-11-04
华南生物医用材料(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a medical composite dressing that can effectively promote wound healing, especially chronic wound healing, and has good mechanical properties and surface morphology, aiming to solve the problem that single-component dressings in the prior art cannot effectively promote chronic wound healing technical problem

Method used

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  • A kind of medical composite dressing and preparation method thereof
  • A kind of medical composite dressing and preparation method thereof
  • A kind of medical composite dressing and preparation method thereof

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preparation example Construction

[0048] Correspondingly, the embodiment of the present invention also provides a preparation method of a medical composite dressing, comprising the following preparation steps:

[0049] S01. Weigh glycerin, chitosan and bioactive glass respectively according to the mass ratio of above-mentioned glycerin, bioactive glass and chitosan;

[0050] S02. Mixing the weighed chitosan, glycerin and bioactive glass in a solvent to form a mixed solution;

[0051] S03. Freezing the mixed solution after standing for defoaming, and then performing vacuum freeze-drying treatment to obtain the medical composite dressing;

[0052] S04. The medical composite dressing is sterilized and packaged.

[0053] Specifically, in the above step S01, the amount of chitosan can be set first, and then the quality of glycerin and bioactive glass can be determined according to the mass ratio of glycerin, bioactive glass to it (as mentioned above, no more details here). . In a preferred embodiment, the chitos...

Embodiment 1

[0064] Dissolve chitosan with a mass fraction of 2.0% in 2.0% (v / v) dilute acetic acid, take 10ml of chitosan solution, add 0.05ml of glycerin to it, stir well, and then press the mass ratio of chitosan to bioactive glass 2 : 1 Add borate bioactive glass, stir evenly, pour into self-made mold after standing for degassing, freeze for 12 hours, put into vacuum freeze dryer for freeze-drying for 48 hours, take out, sterilize and package. The prepared samples have better morphology, but are denser (such as Figure 11 ), its microscopic appearance is as Figure 12 , the mechanical properties are shown in Table 1.

Embodiment 2

[0066] Dissolve chitosan with a mass fraction of 2.0% in 2.0% (v / v) dilute acetic acid, take 10ml of chitosan solution, add 0.05ml of glycerin to it, stir well, and then press the mass ratio of chitosan to bioactive glass to be 3 : 1 Add borate bioactive glass, stir evenly, pour into self-made mold after standing for degassing, freeze for 12 hours, put into vacuum freeze dryer for freeze-drying for 48 hours, take out, sterilize and package. The prepared sample has better morphology, smaller pore size and uniform distribution (such as Figure 13 ), its microscopic appearance is as Figure 14 , the mechanical properties are shown in Table 1.

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Abstract

The invention discloses a medicinal composite dressing and a preparation method thereof. The dressing comprises biological active glass, glycerin and chitosan, wherein the mass ratio of chitosan to biological active glass is 4:1-8:1, and the mass ratio of chitosan to glycerin is 8:1-10:3. The composite dressing prepared from the above compositions is relatively good in morphology, excellent in mechanic properties and good in skin wound healing effect, and has substantial treatment effect especially aiming at modern skin chronic wound healing problems. Additionally, the preparation method of the dressing is simple and easy to operate, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of soft tissue repair, in particular to a medical composite dressing and a preparation method thereof. Background technique [0002] The traditional dressing (gauze) only plays the role of simply covering the wound surface, and has poor antibacterial and antibacterial properties, general performance such as breathable, water-permeable and pus-absorbing, the affinity of the skin is not good enough, there is no sustained and controlled release of drugs, and the healing time is long and It is difficult to suppress the disadvantages such as scar formation. With the rapid development of modern medicine, especially molecular biology, new wound dressings are emerging. These dressings can not only cover the wound, but also have the function of promoting tissue repair, providing a growth environment for new tissue, accelerating wound healing and reducing scars. , Prevent bacterial contamination, and have biodegradab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/44
Inventor 赵晓丽吴帅潘浩波高忠明
Owner 华南生物医用材料(深圳)有限公司
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