Loratadine liquid composition

A technology of loratadine and composition, which is applied in the directions of drug combination, drug delivery, medical preparations of inactive ingredients, etc., can solve problems such as tediousness

Inactive Publication Date: 2015-09-30
DALIAN JINSHITAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, in addition to being cumbersome, this method also involves loss of product

Method used

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  • Loratadine liquid composition
  • Loratadine liquid composition
  • Loratadine liquid composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A1

[0112] Embodiment A1: Preparation of the composition of the present invention

[0113] Prescription (prepared in 1000 servings, the prescription for each serving is as follows):

[0114]

[0115] Preparation method: take loratadine, add about 90% of the formula oil, stir to dissolve, add oil to the full amount, and stir evenly to obtain the composition of the present invention, which is a transparent liquid without sediment.

[0116] Half of the liquid medicine of the present embodiment composition prepared above is packed in a glass bottle (also can be a plastic bottle such as a high-density polyethylene bottle), and the other half is prepared into a soft capsule preparation as follows:

[0117] Capsule skin formula: 40% gelatin, 18% glycerin, 7% sorbitol, 35% water.

[0118] By the following steps, the above-mentioned liquid composition of the present invention is wrapped in prepared capsule skins, and each capsule contains 10 mg of active ingredient.

[0119] Take gel...

Embodiment A2

[0120] Embodiment A2: Preparation of the composition of the present invention

[0121] Prescription (prepared in 1000 servings, the prescription for each serving is as follows):

[0122]

[0123] Preparation method: Prepare according to the method of Example A1 to obtain the composition of the present invention. Further, a part of the composition is packaged in a glass bottle, and the other part is prepared into a soft capsule preparation.

Embodiment A3

[0124] Embodiment A3: Preparation of the composition of the present invention

[0125] Prescription (prepared in 1000 servings, the prescription for each serving is as follows):

[0126]

[0127] Preparation method: Prepare according to the method of Example A1 to obtain the composition of the present invention. Further, a part of the composition is packaged in a glass bottle, and the other part is prepared into a soft capsule preparation.

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Abstract

The invention relates to a liquid loratadine composition, in particular to a liquid medicine composition. The liquid loratadine composition comprises, by weight, loratadine 10 parts and oil 50-2000 parts. The invention further relates to a pharmaceutical preparation which can be in a mode of soft capsules, oral liquid or drops. The liquid loratadine composition can be taken orally, has good pharmaceutical property and can be suitable for large population including infants.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to an oil-based pharmaceutical composition, in particular to an oil-based oil pharmaceutical composition of loratadine which can be used orally. The present invention further relates to a preparation method for preparing the liquid oil pharmaceutical composition of the present invention. Background technique [0002] Loratadine (Loratadine), chemical name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine-11-ylidene Base)-1-piperidinecarboxylate ethyl ester, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1- piperidinecarboxylic acid ethyl ester, molecular formula: C22H23ClN2O2, molecular weight: 382.89, structural formula: [0003] [0004] Loratadine is a white or off-white crystalline powder, odorless. Loratadine is easily soluble in methanol, ethanol or acetone, slightly soluble in 0.1mol / L hydrochloric acid solution, and almost ins...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/4545A61K47/12A61K47/14A61K9/48A61P37/08A61P11/02A61P11/00A61P17/00A61P1/08A61P9/10A61P9/14
Inventor 赵如胜王斌
Owner DALIAN JINSHITAN PHARMA
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