Method for constructing related intestinal canal-pancreatic islet regulation axis function evaluation model and application of model

A technology of related functions and evaluation models, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the problems of insulin comparison, inaccurate and incomplete evaluation of insulin secretion mode, and inability to accurately display two-phase insulin secretion, etc.

Inactive Publication Date: 2014-05-14
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

[0012] The purpose of the present invention is to provide a method for constructing a function evaluation model related to the gut-pancreas axis, aiming at solving the problem that the existing detection technology cannot accurately display the bip

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  • Method for constructing related intestinal canal-pancreatic islet regulation axis function evaluation model and application of model
  • Method for constructing related intestinal canal-pancreatic islet regulation axis function evaluation model and application of model
  • Method for constructing related intestinal canal-pancreatic islet regulation axis function evaluation model and application of model

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[0047] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific implementation cases described here are only used to explain the present invention, and are not intended to limit the present invention.

[0048] In an embodiment of the present invention, a method for constructing a function evaluation model related to the intestinal-pancreatic islet regulation axis is provided, including the following steps:

[0049] Step (1), administering different oral hypoglycemic drugs to the subjects at different stages;

[0050] In step (1), the test process is divided into the first to fourth stages, and the types and doses of drugs administered to the subjects in each stage are as follows:

[0051]

[0052] Each selected subject will receive 4 stages of intravenous-oral double ...

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Abstract

The invention provides a method for constructing a related intestinal canal-pancreatic islet regulation axis function evaluation model. The method includes: allowing a subject to take different oral hypoglycemic drugs or blank control in different stages, then performing intravenous-oral dual hyperglycemic clamp tests on the subject in each stage, drawing an area under the curve for a serum insulin value, a C-peptide value, a plasma glucagon value and an active glucagon-like polypeptide-1 (GLP-1) value acquired through the dual hyperglycemic clamp tests in each stage, and applying Metlab to perform 3D (three-dimensional surface fitting on the areas under the curve in one-to-one correspondence to obtain the related intestine-pancreas axis function evaluation model. By the method, two-phase insulin secretion patterns in intravenous-oral glucose stimulation states can be evaluated and compared accurately, besides, intestinal canal hormone effect and insulin-glucagon secretion can be related quantitatively, and accordingly an accurate intestine-pancreas axis effect model evaluation system is obtained.

Description

technical field [0001] The invention belongs to the field of model construction, and in particular relates to a method and application for constructing a function evaluation model related to the intestinal tract-pancreatic islet regulation axis. Background technique [0002] Some researchers pointed out that under the same blood glucose concentration, the insulin secretion stimulated by oral glucose significantly exceeds the insulin secretion induced by intravenous glucose, and then proposed that these incretins may be related to the regulation of postprandial insulin secretion, and this phenomenon is called "The incretin effect". It mainly refers to the release of peptides secreted by intestinal cells, including glucagon-like polypeptide-1 (GLP-1) and insulinotropic polypeptide (GIP), into the circulation in a glucose-dependent manner, by activating the G protein on the surface of β cells Coupling receptors, increasing the release of cyclic adenosine monophosphate (cAMP), ...

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Application Information

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IPC IPC(8): G06F19/00G06F19/12
Inventor 宁光王卫庆张翼飞池洁陈惠敏郑昇伍贻新
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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