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Application of dizziness-relieving and calming tablet in preparing medicine for inhibiting cell proliferation of embryonal carcinoma cell F9

A teratoma cell and cell proliferation technology, which is applied in the field of preparation of Zhixuan Anshen Tablets, can solve the problems of large dosage for patients, impact on application, and many impurities, and achieve the goal of no bitterness in dosage, reduced dosage, and small dosage Effect

Inactive Publication Date: 2014-05-21
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Zhixuan Anshen Granules in the preparation of drugs for inhibiting the proliferation of teratoma cell F9 cells, and there is no report on the use of supercritical and microwave technology in the extraction and preparation of Zhixuan Anshen Granules. The method of extracting volatile oil and decocting in water, the process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 400g of deerbite grass, 160g of epimedium, 160g of astragalus, 140g of angelica, 200g of chuanxiong, 240g of kudzu root, 120g of fried Atractylodes macrocephala, 140g of Suanzaoren, 120g of pinellia, 120g of Alisma, 100g of dried ginger, 100g of licorice, and dry ginger , Rhizoma Chuanxiong, fried Atractylodes macrocephala, Chinese angelica, and deerbite were added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 320min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added with 6.5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice, each 8 minutes each time,...

Embodiment 2

[0027] Take 400g of deerbite grass, 160g of epimedium, 160g of astragalus, 140g of angelica, 200g of chuanxiong, 240g of kudzu root, 120g of fried Atractylodes macrocephala, 140g of Suanzaoren, 120g of pinellia, 120g of Alisma, 100g of dried ginger, 100g of licorice, and dry ginger , Rhizoma Chuanxiong, fried Atractylodes macrocephala, Chinese angelica, and deerbite were added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 300min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 6.5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. Combine the extr...

Embodiment 3

[0030] Take 400g of deerbite grass, 160g of epimedium, 160g of astragalus, 140g of angelica, 200g of chuanxiong, 240g of kudzu root, 120g of fried Atractylodes macrocephala, 140g of Suanzaoren, 120g of pinellia, 120g of Alisma, 100g of dried ginger, 100g of licorice, and dry ginger , Rhizoma Chuanxiong, fried Atractylodes macrocephala, Chinese angelica, and deerbite were added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 340min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added with 6.5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. After 10 minutes, the extr...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to application of a dizziness-relieving and calming tablet in preparing a medicine for inhibiting cell proliferation of an embryonal carcinoma cell F9 and a preparation method of the dizziness-relieving and calming tablet. According to the application of the dizziness-relieving and calming tablet in preparing the medicine for inhibiting cell proliferation of the embryonal carcinoma cell F9, the dizziness-relieving and calming tablet is prepared from the following bulk drugs: 400g of pyrola, 160g of epimedium, 160g of astragalus membranaceus, 140g of Chinese angelica, 200g of ligusticum wallichii, 240g of kudzu vine root, 120g of fried bighead atractylodes rhizome, 140g of spina date seed, 120g of prepared pinellia ternata, 120g of rhizoma alismatis, 100g of dried ginger, and 100g of liquorice. The dizziness-relieving and calming tablet is prepared by adopting supercritical extraction and microwave extraction, so that the content of icariin can be greatly improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Zhixuan Anshen Tablets in the preparation of drugs for inhibiting the proliferation of teratoma cell F9 cells and the preparation method of Zhixuan Anshen Tablets. Background technique [0002] The standard number of Zhixuan Anshen Granules is WS-11411 (ZD-1411)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Standards. Made from 400g of Herba pilus, 160g of Epimedium, 160g of Astragalus, 140g of Angelica, 200g of Rhizoma Chuanxiong, 240g of Pueraria Rhizoma, 120g of Fried Atractylodes Rhizome, 140g of Suanzaoren, 120g of Zhipinellia, 120g of Alisma, 100g of Dried Ginger, and 100g of Licorice. It has the effects of nourishing the liver and kidney, replenishing qi and blood, and calming the mind. For liver and kidney deficiency, dizziness, tinnitus, insomnia, palpitation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/20A61P35/00
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
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