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A composition for increasing hemoglobin concentration in an individual

A composition and heme technology, applied in the composition for supplementing iron or alleviating menstrual pain, in the field of treating anemia, and achieving the effect of alleviating menstrual pain

Active Publication Date: 2019-07-16
MICROBIO (SHANGHAI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are products on the market that contain angelica, chuanxiong, white peony, rehmannia glutinosa, longan, black jujube and other Chinese herbal medicines combined with iron, there is no literature or scientific report on the relationship between the four substances and iron absorption

Method used

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  • A composition for increasing hemoglobin concentration in an individual
  • A composition for increasing hemoglobin concentration in an individual
  • A composition for increasing hemoglobin concentration in an individual

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, animal experiments

[0035] A. Experimental animals: male Wistar rats

[0036] B. Biochemical and chemical reagents:

[0037] 1. AIN93G feed (as shown in Table 1):

[0038] Table 1 AIN93G iron-deficiency feed formula

[0039]

[0040] 2. Four substance extract powder:

[0041] The four medicinal materials of Angelica, Chuanxiong, Paeoniae Alba and Rehmannia glutinosa with a weight ratio of 3:3:1:1 were used to prepare the four-material extract, which was then dried to make a powder.

[0042] 3. Ferrous glycinate powder:

[0043] Grind ferrous glycinate into powder.

[0044] C. Design of animal experiments:

[0045] The animal experiments were divided into two stages: the iron deficiency period and the regeneration period.

[0046] 1. Iron deficiency period

[0047] Feed the rats with AIN93G feed without adding iron, take food freely, and record the feed intake for about two to four weeks to make the rats reach the required level of iron-deficien...

Embodiment 2

[0059] Embodiment 2, human clinical trial

[0060] A. Subjects:

[0061] Women who are over 12 years old and have not stopped menstruation, who suffer from iron deficiency anemia, and blood tests show that hemoglobin is between 8 and 12g / dL, and their serum iron is lower than 12μg / L, and these subjects are enrolled in the clinic You must be non-pregnant during the test period.

[0062] B. Drugs:

[0063] According to the present invention, ferrous glycinate powder plus Siwu extract powder (abbreviated as "composition of the present invention") aqueous solution 50ml, which contains 393.75mg angelica, 393.75mg Chuanxiong, 131.25mg Radix Paeoniae Alba and 131.25mg Rehmannia glutinosa (i.e. The weight ratio of the four medicinal materials is 3:3:1:1), and 50mg of ferrous glycinate, relative to the total weight of ferrous glycinate and the four extracts, glycine The weight percentage of ferrous iron is about 5%-10%, such as about 10%.

[0064] C. Experimental design

[0065] 1...

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Abstract

The present invention discloses a composition with a multiplying effect and capable of curing anemia, increasing irony supplement, and alleviating menstrual pain. The composition mainly comprises four abstracts, namely angelica sinensis, ligusticum wallichii, radix paeoniae alba, and prepared rehmannia root, and takes ferrous bisglycinate chelate as an active component. The four abstracts and ferrous bisglycinate chelate are combined on ratio to generate a multiplying effect, and thereby forming the composition. The composition is especially useful for females having iron-deficiency anemia, and is capable of providing irony for female to absorb thereby improving a multiplying effect of hemoglobin concentration, and alleviating menstrual pain.

Description

technical field [0001] The present invention relates to a composition for treating anemia, supplementing iron or alleviating menstrual pain with synergistic effects. Specifically, the present invention relates to a composition with synergistic effects, which provides better effects of promoting iron absorption, hemoglobin production and treating anemia, and has the effect of alleviating menstrual pain. Background technique [0002] Anemia can be roughly divided into three categories: (1) Abnormalities of bone marrow production, such as aplastic anemia, malignant tumors invading the bone marrow, such as leukemia; (2) disorders in the maturation of red blood cells, such as pernicious anemia caused by vitamin B12 deficiency iron anemia; and (3) loss or destruction of blood, such as bleeding from injury, iron deficiency anemia, or destruction of red blood cells from various causes. [0003] Most people with anemia have iron deficiency anemia, which is the result of anemia due t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P7/06A61P3/02A61P15/00A61P29/00A61K31/295
Inventor 路孔明
Owner MICROBIO (SHANGHAI) CO LTD
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