A kind of enteric-coated vegetable hollow capsule and preparation method thereof

A plant hollow capsule, enteric-coated technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and non-active ingredients medical preparations, can solve the problems of affecting the qualified rate of finished products, poor flowability of raw materials, and high water loss, and achieve no water content. Easy, good printability, good dispersion effect

Active Publication Date: 2017-09-08
SHAOXING KANGKE CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the following problems are prone to occur in the production process of plant-based hollow capsules: if the water content of the product raw materials is low (more solids), the fluidity and homogeneity of the raw materials are poor, and the produced hollow capsules are different due to the material and wall thickness of each site. Inconsistent and low qualified rate of finished products
If the water content of the product raw materials is increased, the fluidity of the raw materials will be improved, the drying and molding process of the product will be longer, and the power consumption will increase. Moreover, due to the loss of water, the uncertainty of product molding will increase, which will also affect the qualified rate of finished products.
The empty capsules prepared by the existing production process have the disadvantages of different wall thicknesses, large differences in water content, low pass rate, and high energy consumption, and the traditional gelatin empty capsules disintegrate and release within 10 minutes in gastric acid, but the capsules The contents in it are irritating to the stomach, or unstable in case of acid, and need to be disintegrated in the intestine to exert curative effect

Method used

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  • A kind of enteric-coated vegetable hollow capsule and preparation method thereof
  • A kind of enteric-coated vegetable hollow capsule and preparation method thereof
  • A kind of enteric-coated vegetable hollow capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of enteric-coated vegetable hollow capsule embodiment 1 of the present invention comprises the following components, and each component is respectively according to parts by weight:

[0039]

[0040] Wherein, the modified plant glue comprises the following components, and each component is respectively by weight:

[0041]

[0042] The preparation method of this kind of enteric-coated vegetable hollow capsule is as follows: add hypromellose and appropriate amount of water in the reaction kettle, the amount of water added is suitable for fully dissolving the hypromellose, heat up to 60°C, stir evenly, Raise the temperature to 80°C, add carrageenan, continue to stir evenly, raise the temperature to 95°C, add Tween 80, continue to stir evenly, and let stand to react for 3 hours; The solid content of the product is 30%, and a modified vegetable glue is obtained; after mixing the modified vegetable glue, succinic anhydride, sodium alginate, hypromellose phthalate...

Embodiment 2

[0043] A kind of enteric-coated vegetable hollow capsule embodiment 2 of the present invention comprises the following components, and each component is respectively according to parts by weight:

[0044]

[0045]

[0046]Wherein, the modified plant glue comprises the following components, and each component is respectively by weight:

[0047]

[0048] The preparation method of this kind of enteric-coated vegetable hollow capsule is as follows: add hypromellose and appropriate amount of water in the reaction kettle, the amount of water added is suitable for fully dissolving the hypromellose, heat up to 75°C, stir evenly, Raise the temperature to 85°C, add carrageenan, continue to stir evenly, raise the temperature to 90°C, add Tween 80, continue to stir evenly, and let stand to react for 5 hours; The solid content of the product is 30%, and a modified vegetable glue is obtained; after mixing the modified vegetable glue, succinic anhydride, sodium alginate, hypromellos...

Embodiment 3

[0049] Embodiment 3 of an enteric-coated vegetable hollow capsule of the present invention comprises the following components, and each component is respectively by weight:

[0050]

[0051]

[0052] Wherein, the modified plant glue comprises the following components, and each component is respectively by weight:

[0053]

[0054] The preparation method of this kind of enteric-coated vegetable hollow capsule is as follows: add hypromellose and appropriate amount of water in the reaction kettle, the amount of water added is suitable for fully dissolving the hypromellose, heat up to 65°C, stir evenly, Raise the temperature to 78°C, add carrageenan, continue to stir evenly, raise the temperature to 88°C, add Tween 80, continue to stir evenly, and let stand to react for 2 hours; The solid content of the product is 30%, and a modified vegetable glue is obtained; after mixing the modified vegetable glue, succinic anhydride, sodium alginate, hypromellose phthalate, and fumar...

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Abstract

The invention discloses an enteric-coated plant hollow capsule, which comprises: 100 parts by weight of modified plant glue; 3-8 parts by weight of succinic anhydride; 10-30 parts by weight of sodium alginate; hypromellose 0.2-0.8 parts by weight of phthalates; 0.2-0.8 parts by weight of fumaric acid; wherein the modified vegetable glue includes: 100 parts by weight of hypromellose; 10-25 parts by weight of carrageenan ; Tween 80 4-12 parts by weight; appropriate amount of water. The preparation method of the enteric-coated vegetable hollow capsule is also disclosed. The invention can effectively control the water content of the product raw materials, and at the same time maintain the fluidity of the product raw materials at a higher level, so that the performance of the produced capsule shell is more excellent, and the qualified rate of the finished product is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical excipients, relates to an enteric-coated vegetable hollow capsule, and also relates to a preparation method of the enteric-coated vegetable hollow capsule. Background technique [0002] Enteric-coated hollow capsule, also known as capsule shell, means that the capsule shell is insoluble in gastric juice, but can disintegrate or dissolve in intestinal juice to release the drug in the capsule. The capsule shell is also the main auxiliary material for processing pharmaceutical capsule preparations. Currently used enteric-coated empty capsules are processed and shaped by gelatin and coated with an anti-gastric acid enteric coating material. The gelatin is firstly soaked in purified water, swollen, and then gelatinized, and then sent to the capsule production line to be dipped in glue, dried and solidified to obtain gelatin hollow capsule material, and then enteric-coated on the surface of the g...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/22A61K47/26A61K47/12
Inventor俞愈王孟军俞三愈
OwnerSHAOXING KANGKE CAPSULE