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Brain blood oxygen level measuring method based on magnetic resonance

A measurement method and technology of blood oxygen level, applied in the direction of diagnostic recording/measurement, blood characterization device, medical science, etc., to achieve the effect of good magnetic susceptibility value

Active Publication Date: 2015-04-08
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Problems solved by technology

There is another kind of near-infrared spectroscopy (Near infrared spectroscopy: NIRS). NIRS obtains their values ​​according to the absorption of different wavelengths of near-infrared light by oxygenated and deoxygenated hemoglobin in venous blood, so that they can be further measured relative concentration to measure OEF, but this method produces adverse reactions from the skull, cerebrospinal fluid, marrow, ambient light, and extracranial tissue drainage

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  • Brain blood oxygen level measuring method based on magnetic resonance
  • Brain blood oxygen level measuring method based on magnetic resonance
  • Brain blood oxygen level measuring method based on magnetic resonance

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[0031] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the present invention will be further described in detail below in conjunction with the embodiments and the accompanying drawings. Here, the exemplary embodiments and descriptions of the present invention are used to explain the present invention, but not to limit the present invention.

[0032] The quantitative susceptibility imaging technique (Quantitative Susceptibility Mapping: QSM) is based on the paramagnetic characteristics of deoxygenated hemoglobin in the venous blood vessels, which will produce local magnetic field inhomogeneity in magnetic resonance, and show the characteristics of rapid dephasing. , to measure the magnetic sensitivity of brain tissue through its phase change, so as to effectively measure the venous oxygen saturation value of the brain according to the magnetic sensitivity value. This measurement method QSM has been successf...

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Abstract

The invention provides a brain blood oxygen level measuring method based on magnetic resonance. The measuring method includes acquiring an amplitude diagram and a phase diagram of brain tissues; standardizing the amplitude diagram into a noise SD diagram, and acquiring a standardized diagram Ic according to linear fitting of the noise SD diagram; unwrapping the phase diagram to acquire a standard field diagram; putting the standard field diagram and the standardized diagram Ic into a regularization constraint rule to acquire a magnetism sensitiveness matrix without an ambient field; acquiring a vein oxygen saturation value and an oxygen metabolism parameter according to the magnetism sensitiveness matrix. The brain blood oxygen level measuring method has the advantages that magnetic field phase changes generated by air tissues are removed, so that magnetism sensitiveness values of the tissues are regained better, and venous blood oxygen saturation Yv and residual saturation of hemoglobin in venous blood, namely an oxygen extraction fraction (OEF), are acquired.

Description

technical field [0001] The invention relates to the field of magnetic resonance image processing, in particular to a magnetic resonance brain blood oxygen level measurement method. Background technique [0002] Oxygen saturation refers to the percentage of hemoglobin combined with oxygen to achieve saturation. It is a very important parameter for measuring blood oxygen levels. The normal value of arterial oxygen saturation (Ya) is 97%, and the venous oxygen saturation value is generally 50%- 75%, here, mainly to measure venous oxygen saturation. The venous oxygen fraction Yv has a direct relationship with the blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal. As we all know, the BOLD fMRI signal has a very complicated relationship with blood oxygen, blood flow and brain oxygen consumption, so Evaluating the measurement of Yv can better understand the BOLD signaling mechanism, and can also be used to evaluate other physiological paramete...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/145
CPCA61B5/055A61B5/14542
Inventor 史彩云张丽娟谢国喜张晓咏刘新
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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