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Traditional Chinese medicine composition and application thereof for treating infertility and menstrual disorders of luteal phase insufficiency

A technology for menstrual disorders and infertility, which is applied in drug combinations, medical preparations containing active ingredients, sexual diseases, etc., can solve the problems of low clinical pregnancy rate, etc., so as to relax the heart and liver qi, stabilize the heart, liver and soul, and achieve precise curative effects. Effect

Active Publication Date: 2017-09-22
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although artificial assisted reproductive technology (IVF-ET) has achieved great success in the treatment of infertility, its clinical pregnancy rate is still low, and LPD is one of the main reasons

Method used

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  • Traditional Chinese medicine composition and application thereof for treating infertility and menstrual disorders of luteal phase insufficiency
  • Traditional Chinese medicine composition and application thereof for treating infertility and menstrual disorders of luteal phase insufficiency
  • Traditional Chinese medicine composition and application thereof for treating infertility and menstrual disorders of luteal phase insufficiency

Examples

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Effect test

Embodiment 1

[0026] 1. A Chinese medicinal composition for treating infertility and menstrual disorders of corpus luteum insufficiency, which is made from the following raw materials in parts by weight:

[0027]

[0028] 2. A method for preparing a Chinese medicinal composition for treating infertility and menstrual disorders of luteal phase insufficiency, comprising the following steps:

[0029] (1) Take 6 parts of fried white peony, 9 parts of Chinese yam, 6 parts of dogwood, 3 parts of vinegar Bupleurum, 9 parts of silkworm, 9 parts of antler slices, 9 parts of amethyst, and 6 parts of purple salvia, soak in water for 1 hour , put it in a multi-functional extraction tank, add water to decoct twice, add 5 times the amount of water of the medicinal materials for the first time, decoct for 2 hours, and filter the decoction. For the second time, add 3 times the amount of water of the medicinal materials, decoct for 1.2 hours, take two decoctions, filter, take the filtrate into a heat-sea...

Embodiment 2

[0031] 1. A traditional Chinese medicine composition for treating infertility and menstrual disorders of corpus luteum insufficiency, which is made from the following raw materials in parts by weight:

[0032]

[0033] 2. A method for preparing a Chinese medicinal composition for treating infertility and menstrual disorders of luteal phase insufficiency, comprising the following steps:

[0034] Take 1 part of fried white peony, 1 part of Chinese yam, 1 part of dogwood, 0.5 part of vinegar Bupleurum, 1 part of silkworm, 1.5 parts of antler slices, 1.5 parts of amethyst, 1 part of purple salvia, soak in water for 1 hour, set aside In the functional extraction tank, add water to decoct twice, the first time add 8 times the amount of water of the medicinal materials, decoct for 1 hour, take the decoction and filter. For the second time, add 6 times the amount of water of the medicinal materials, decoct for 1 hour, take two decoctions, filter, add carrier lactose or corn starch,...

Embodiment 3

[0036] 1. A traditional Chinese medicine composition for treating infertility and menstrual disorders of corpus luteum insufficiency, which is made from the following raw materials in parts by weight:

[0037] Stir-fried white peony 3 parts, Chinese yam 5 parts, dogwood 3 parts, vinegar Bupleurum 1.5 parts

[0038] 5 parts of silkworm, 3 parts of antler slices, 5 parts of amethyst, 3 parts of purple salvia.

[0039] 2. A method for preparing a Chinese medicinal composition for treating infertility and menstrual disorders of luteal phase insufficiency, comprising the following steps:

[0040]First, take 3 parts of fried white peony, 5 parts of Chinese yam, 3 parts of dogwood, 1.5 parts of vinegar Bupleurum, 5 parts of silkworm, 3 parts of antler slices, 5 parts of amethyst, and 3 parts of purple salvia. Soak in 10 times the amount of water for 2 hours, then decoct once for 2 hours each time, add 8 times the amount of water for the second time and decoct for 1.2 hours, combine ...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating luteal phase defect type infertility and menstrual disorder. The traditional Chinese medicine composition disclosed by the invention is prepared from the following components in parts by weight: 1-6 parts of fried radix paeoniae alba, 1-9 parts of common yam rhizome, 1-6 parts of dogwood, 0.5-3 parts of vinegar baked bupleurum root, 1-9 parts of the seed of Chinese dodder, 1.5-9 parts of sliced cornu cervi, 1.5-9 parts of amethyst and 1-6 parts of radix salviae miltiorrhizae. According to the compound composition provided by the invention, by means of syndrome differentiation and treatment, the formula is obtained through a lot of experimental screening under the guidance of theories of traditional Chinese medicines; experimental results show that the traditional Chinese medicine composition is capable of improving the structure and form of ovary mitochondria endoplasmic reticulum, improving structures of endometrial glands and mesenchyme, adjusting ovary secreted active substances E2 and P, reducing endometrium estrogen receptors and progestrone receptors and increasing expression of integrins alpha v and beta 3; therefore, the endometrium receptivity can be increased; the embryo implantation action is promoted; the traditional Chinese medicine composition has the good effect for treating infertility; and furthermore, the traditional Chinese medicine composition is free from toxic and side effect, and safe and reliable to use.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating infertility and menstrual disorders due to corpus luteum insufficiency and its application. Background technique [0002] In recent years, infertility is still one of the three major refractory diseases in the medical field. Clinical studies have found that luteal phase defect (LPD) is a direct and important cause of pregnancy failure in women of childbearing age. Luteal phase insufficiency (LPD) refers to the development and dysfunction of the corpus luteum (a temporary endocrine organ closely related to reproduction) formed by follicles after ovulation, insufficient secretion of progesterone, poor endometrial secretion and menstrual disorders. The clinical characteristics are: Infertility and recurrent early miscarriages. About 3.5% to 10% of infertility, 35% of early pregnancy abortion and 4% to 60% of habitu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P15/08A61P15/00A61K33/14A61K35/32
CPCA61K9/1652A61K9/2059A61K9/4866A61K33/14A61K35/32A61K36/233A61K36/39A61K36/40A61K36/537A61K36/65A61K36/71A61K36/8945A61K2300/00
Inventor 周惠芳夏桂成
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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