A preparation method of transfer factor and preparation method of injection thereof

A technology of transfer factor and water for injection, applied in peptide preparation methods, chemical instruments and methods, medical preparations containing active ingredients, etc., can solve problems such as unqualified abnormal toxicity, restricted use, and large filter membrane load, etc., to achieve Ensure clinical safety, prolong service life, and ensure product quality
CN104644673BActive Publication Date: 2018-08-24武汉华龙生物制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
武汉华龙生物制药有限公司
Publication Date
2018-08-24

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Abstract

The invention discloses a preparation method of a transfer factor. The preparation method of the transfer factor is characterized by comprising the steps: pre-processing, homogenation, repeated freeze thawing, centrifugation, ethanol precipitation, primary ultra-filtration, virus inactivation and secondary ultra-filtration. The invention also discloses a preparation method of a transfer factor injection. According to an ethanol precipitation method and a virus deactivation method which are not adopted in a traditional process, various impurity proteins are removed, and various animal source viruses are effectively removed, so that the security of products can be effectively guaranteed, sensitive sources are reduced, and the security is improved; meanwhile, by adopting an ethanol precipitation method, the impurity proteins are removed, so that the ultra-filtration load of a subsequent ultrafiltration membrane can be reduced, and the service life of the ultrafiltration membrane is prolonged.
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Description

technical field

[0001] The invention relates to the field of biopharmaceuticals, in particular to a method for preparing transfer factor and a method for preparing an injection thereof. Background technique

[0002] Transfer Factor (TF), also known as transfer factor, is produced by lymphocytes with cellular immune function, and is a dialyzable factor obtained from freeze-thawed sensitized T cells. It can strengthen the immunity of animals, and can transfer the ability of delayed allergic reaction from one individual (including humans and animals) to another individual, and they transport the antigen-specific cellular immunity (delayed allergic reaction) of parent lymphocytes to unexposed or primary lymphocytes. Transfer factor carries the specific immune information of sensitized lymphocytes, and can present specific immune information to recipient lymphocytes, so that recipient inactive lymphocytes can be transformed into specific sensitized lymphocytes, thereby stimulati...

Claims

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