HPV/Cyaa-based chimeric proteins and their use in inducing immune responses against HPV infection and HPV-induced disease
一种嵌合蛋白、蛋白的技术,应用在嵌合蛋白领域,能够解决无保护性细胞免疫应答、抗原细胞免疫应答弱等问题
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[0352] I. Materials and methods
[0353] mouse
[0354] Six-week-old female C57BL / 6 mice (H-2 b ). Mice were housed under pathogen-free conditions with ad libitum access to water and food. Procedures involving animals and their care complied with Genticel guidelines, which adhere to national and international laws and policies, and were reviewed by local ethics committees.
[0355] For some of the HPV types used in the present invention, other mice with different genetic backgrounds can be advantageously used. Such mice can be purchased from Janvier Laboratories and include: DBA / 2JRi (H2K d / H2D d ), or CBA / JRi(H2K k / H2D k )SJL / JRi(H2K s / H2D s ) and FVB / NRi (H2K q / H2D q ).
[0356] Other mice, such as humanized mice, which have HLA, particularly the HLA-A2 haplotype, are also of interest in determining the immune response elicited by the constructs of the invention. Transgenic HLA-A2.1 mice can be purchased from TACONIC (USA) in mice expressing the human HLA-...
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