Medicinal gel for chronic periodontitis as well as preparation method and application thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for chronic periodontitis and gel, applied in the field of Jiawei Wudan powder drug gel and its preparation, can solve the problems of being easily affected by other factors, prone to errors in results, and poor in quantification, and achieves the goal of promoting scientific development, Affordable, non-toxic effects
Active Publication Date: 2020-08-25
钟瑾 +1
View PDF4 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0007] In addition, although the detection of periodontitis progress by periodontal indicators and peripheral blood inflammatory mediators is recognized by experts, there are problems such as poor quantification, strong subjectivity, low sensitivity, easy to be affected by other factors, and easy to have errors in the results. Traditional Chinese medicine compound preparations Slow-release gel still needs more research before it can be promoted
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0042] Embodiment 1: Preparation of the modified Wudan powder drug gel for chronic periodontitis.
[0043] Preparation of drug gel for chronic periodontitis, which contains carrier, traditional Chinese medicine ingredients, water and sodium β-glycerophosphate; carrier consists of N-methyl-2-pyrrolidone, glycerol triacetate, polylactic acid-glycolic acid copolymer A blend of traditional Chinese medicine ingredients including Danshen, Galla, Bletilla striata, Astragalus, Coptis, and cinnamon extracts.
[0044] Preferably, the polylactic acid-glycolic acid copolymer in the drug gel is 40% by mass percentage, and the ratio of the polylactic acid-glycolic acid copolymer is 75 / 25, that is, PLGA75:25; N-methyl-2- The volume ratio of pyrrolidone and triacetin is 5:5.
[0045] The medicinal gel contains 15% of traditional Chinese medicine ingredients, 4% of beta-glycerophosphate sodium and 30% of water in volume percentage.
[0046] The extracts of Salvia Miltiorrhiza, Galla Chinensi...
Embodiment 2
[0063] Example 2: Verification of the modified Wudan powder drug gel for chronic periodontitis.
[0064] The treatment group Jiawei Wudansan gel group and the control group tetracycline gel group completed the following treatments on the basis of periodontal basic treatment. see figure 1 shown.
[0065] Subject grouping and treatment: Take 100 cases of chronic periodontitis as observation objects, aged 18-80 years old, male or female, they are randomly divided into Chinese medicine gel group A and western medicine gel group by random number table method on the basis of standardized SPR Group B had 50 cases in each group. Group A was treated with periodontal topical modified Wudan powder gel, and group B was treated with tetracycline sustained-release gel locally. Both drugs were administered once a week, and one week was a course of treatment. After 4 courses of treatment, comparisons were made. 2 groups of treatment effects.
[0066] Efficacy evaluation indicators: the fol...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses medicinal gel for chronic periodontitis as well as a preparation method and application thereof. The medicinal gel comprises a carrier, traditional Chinese medicine components,water and beta-sodium glycerophosphate; the carrier is formed by mixing N-methyl-2-pyrrolidone, glyceryl triacetate and a polylactic acid-glycolic acid copolymer; and the traditional Chinese medicinecomponents comprise salvia miltiorrhiza, gallnut, bletilla striata, astragalus membranaceus, coptis chinensis and cinnamon extract. The volume fraction of the traditional Chinese medicine componentsin the gel is 15%, the volume fraction of the sodium beta-glycerophosphate is 4%, the volume fraction of the water is 30%, the mass fraction of the polylactic acid-glycolic acid copolymer is 40%, andthe volume ratio of the N-methyl-2-pyrrolidone to the glyceryl triacetate is 5:5. The invention also provides the preparation method and application of the medicinal gel. The gel disclosed by the invention is relatively simple and convenient to prepare, has good biocompatibility and adhesiveness, is good in local administration absorption and less in adverse reaction, also has traditional Chinesemedicine components, and has the advantages of high efficiency, no toxic or side effect, convenience in use, moderate price and the like.
Description
technical field [0001] The present invention relates to a drug gel for auxiliary treatment of chronic periodontitis and its preparation method and application, in particular, to a modified Wudan powder drug gel for chronic periodontitis, its preparation method and application . Background technique [0002] Chronic periodontitis is a chronic infectious disease. It is a multifactorial disease determined by bacteria, host and environment. The interaction between microorganisms and host determines the process and progress of the disease. The antigenic components of plaque bacteria and the toxins and enzymes they produce can directly cause damage to periodontal tissue, and can also trigger host immune and inflammatory responses, indirectly causing damage to periodontal tissue and other systemic lesions throughout the body. The host's immune response can protect the periodontal tissue in the early stage and prevent pathogenic bacteria from invading the periodontal tissue, but so...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more