Medicinal gel for chronic periodontitis as well as preparation method and application thereof
A technology for chronic periodontitis and gel, applied in the field of Jiawei Wudan powder drug gel and its preparation, can solve the problems of being easily affected by other factors, prone to errors in results, and poor in quantification, and achieves the goal of promoting scientific development, Affordable, non-toxic effects
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Embodiment 1
[0042] Embodiment 1: Preparation of the modified Wudan powder drug gel for chronic periodontitis.
[0043] Preparation of drug gel for chronic periodontitis, which contains carrier, traditional Chinese medicine ingredients, water and sodium β-glycerophosphate; carrier consists of N-methyl-2-pyrrolidone, glycerol triacetate, polylactic acid-glycolic acid copolymer A blend of traditional Chinese medicine ingredients including Danshen, Galla, Bletilla striata, Astragalus, Coptis, and cinnamon extracts.
[0044] Preferably, the polylactic acid-glycolic acid copolymer in the drug gel is 40% by mass percentage, and the ratio of the polylactic acid-glycolic acid copolymer is 75 / 25, that is, PLGA75:25; N-methyl-2- The volume ratio of pyrrolidone and triacetin is 5:5.
[0045] The medicinal gel contains 15% of traditional Chinese medicine ingredients, 4% of beta-glycerophosphate sodium and 30% of water in volume percentage.
[0046] The extracts of Salvia Miltiorrhiza, Galla Chinensi...
Embodiment 2
[0063] Example 2: Verification of the modified Wudan powder drug gel for chronic periodontitis.
[0064] The treatment group Jiawei Wudansan gel group and the control group tetracycline gel group completed the following treatments on the basis of periodontal basic treatment. see figure 1 shown.
[0065] Subject grouping and treatment: Take 100 cases of chronic periodontitis as observation objects, aged 18-80 years old, male or female, they are randomly divided into Chinese medicine gel group A and western medicine gel group by random number table method on the basis of standardized SPR Group B had 50 cases in each group. Group A was treated with periodontal topical modified Wudan powder gel, and group B was treated with tetracycline sustained-release gel locally. Both drugs were administered once a week, and one week was a course of treatment. After 4 courses of treatment, comparisons were made. 2 groups of treatment effects.
[0066] Efficacy evaluation indicators: the fol...
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