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A kind of medicinal gel for chronic periodontitis and preparation method and use thereof

A technology for chronic periodontitis and gel, applied in the field of Jiawei Wudan powder drug gel and its preparation, can solve the problems of low sensitivity, strong subjectivity, poor quantification and the like, and achieves good market prospects and no toxic and side effects. , moderate price effect

Active Publication Date: 2022-07-08
钟瑾 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, although the detection of periodontitis progress by periodontal indicators and peripheral blood inflammatory mediators is recognized by experts, there are problems such as poor quantification, strong subjectivity, low sensitivity, easy to be affected by other factors, and easy to have errors in the results. Traditional Chinese medicine compound preparations Slow-release gel still needs more research before it can be promoted

Method used

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  • A kind of medicinal gel for chronic periodontitis and preparation method and use thereof
  • A kind of medicinal gel for chronic periodontitis and preparation method and use thereof
  • A kind of medicinal gel for chronic periodontitis and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of Jiawei Wudan Powder medicinal gel for chronic periodontitis.

[0043] A pharmaceutical gel for chronic periodontitis is prepared, which comprises a carrier, traditional Chinese medicine ingredients, water and β-glycerosodium phosphate; the carrier is composed of N-methyl-2-pyrrolidone, triacetin, polylactic acid-glycolic acid copolymer Mixed, Chinese herbal ingredients include Salvia, Galla japonica, Bletilla striata, Astragalus, Rhizoma Coptidis, and Cinnamon extract.

[0044] Preferably, the polylactic acid-glycolic acid copolymer in the drug gel is 40% by mass, and the ratio of the polylactic acid-glycolic acid copolymer is 75 / 25, that is, PLGA75:25; N-methyl-2- The volume ratio of pyrrolidone and triacetin was 5:5.

[0045] The medicine gel contains 15% of traditional Chinese medicine, 4% of beta-glycerophosphate and 30% of water.

[0046] The extracts of Salvia miltiorrhiza, Galla japonica, Bletilla striata, Astragalus, Coptis chinensis ...

Embodiment 2

[0063] Example 2: Validation of Jiawei Wudan Powder medicinal gel for chronic periodontitis.

[0064] The modified Wudan powder gel group in the treatment group and the tetracycline gel group in the control group completed the following treatments based on the periodontal basic treatment. see figure 1 shown.

[0065] Grouping and treatment of subjects: 100 patients with chronic periodontitis, aged 18-80 years old, male or female, were randomly divided into traditional Chinese medicine gel group A and western medicine gel by random number table method on the basis of standardized SPR. Group B, 50 cases in each group, group A was given adjuvant treatment with periodontal local modified Wudan powder gel, and group B was given local adjuvant treatment with tetracycline sustained-release gel, both of which were administered once a week, one week as a course of treatment, and comparison after 4 courses of treatment 2 groups of treatment effects.

[0066] Efficacy evaluation indic...

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Abstract

The invention discloses a medicinal gel for chronic periodontitis and a preparation method and application thereof. The medicinal gel comprises a carrier, traditional Chinese medicine ingredients, water and β-sodium glycerophosphate; the carrier is made of N-methyl-2-pyrrolidone , triacetin, polylactic acid-glycolic acid copolymer mixed, Chinese medicine ingredients include salvia, gall, Bletilla striata, astragalus, coptis and cinnamon extracts. The volume fraction of traditional Chinese medicine ingredients in the gel is 15%, β-sodium glycerophosphate is 4%, water is 30%, the mass fraction of polylactic acid-glycolic acid copolymer is 40%, N-methyl-2-pyrrolidone and triglyceride The volume ratio of glycerol acetate is 5:5. The invention also provides the preparation method and application of the medicinal gel. The gel of the invention is relatively simple and convenient to prepare, has good biocompatibility and adhesion, good local administration and absorption, few adverse reactions, and also has the advantages of traditional Chinese medicine ingredients, high efficiency, no toxic side effects, convenient use and moderate price. .

Description

technical field [0001] The present invention relates to a medicinal gel for auxiliary treatment of chronic periodontitis, a preparation method and application thereof, in particular to a medicinal gel of Jiawei Wudan Powder for chronic periodontitis, preparation method and application thereof . Background technique [0002] Chronic periodontitis is a chronic infectious disease. It is a multifactorial disease determined by bacteria, host and environment. The interaction between microorganisms and the host determines the process and progression of the disease. The antigenic components of plaque bacteria and the toxins and enzymes produced by them can directly cause the destruction of periodontal tissue, and can also trigger host immune responses and inflammatory responses, and indirectly cause the destruction of periodontal tissue and other systemic lesions in the body. The host's immune response in the early stage can protect the periodontal tissue and prevent pathogenic bac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61K47/14A61K47/22A61K47/34A61P1/02A61P31/04A61P31/10A61K9/06A61K35/64
CPCA61K36/537A61K35/64A61K36/898A61K36/481A61K36/718A61K36/54A61K9/06A61K47/34A61K47/14A61K47/22A61K9/0063A61P1/02A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 钟瑾赵晓山
Owner 钟瑾
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