Pediatric oral sedatives

Abstract

The invention discloses an oral sedative for children. The sedative comprises the following components: simple syrup, a chloral hydrate solution with a mass concentration of 10%-20%, and a glucose solution containing sodium citrate with a mass concentration of 5%-10%. Its volume ratio is 1-2:2:1, the mass concentration of the glucose solution dissolving sodium citrate is 5%-10%, the main component of the simple syrup is the simple syrup of sucrose, and the oral sedative after mixing has a pH value of 7 ‑8 weakly alkaline solution. The sedative formula of the present application: (1) improves the mouthfeel of existing chloral hydrate, reduces the resistance reaction when infant patient takes; It is absorbed by the small intestine and improves bioavailability, thereby reducing the irritation to the gastrointestinal tract and reducing the occurrence of nausea and vomiting.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and more precisely relates to a sedative pharmaceutical preparation, in particular to an oral sedative for infants and young children. Background technique [0002] Sedative drugs are mainly used in the treatment of mental diseases. Their main effect is to relieve people's depression and anxiety, and to treat inability to sleep caused by mental stress. Commonly used sedative drugs include phenobarbital, meproton, chlordiazepoxide, and diazepam. However, the use of these drugs is strictly restricted to pregnant women and children. Even people with normal health who take stable sedative drugs for a long time will have side effects: drowsiness, inability to concentrate, unresponsiveness, memory loss, dizziness, etc. [0003] For children with mental stress, especially children who are examined in general pediatrics, blood tests and other tests are usually required to diagnose th...

AI Technical Summary

Problems solved by technology

[0005] But chloral hydrate mouthfeel is very poor, has very strong bitter taste and pungent taste, and infants and young children can appear violent crying resistance when oral; It is easy to vomit after being stimulated, and the medicine that has been taken is vomited out, and because the amount of medicine vomited out cannot be estimated, if it is taken orally again, it may lead to excessive drug intake and poisoning, which will cause various inspections of the disease to be impossible; and if The method of enema administration to sick children must be fixed by compulsory measures before the liquid medicine can be poured in. In the process of forcing the children to act, it is easy to cause physical harm to the children and affect the treatment.

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