Method for taking molecular marker in diagnosis and prognosis evaluation of breast cancer

A technique for molecular markers and prognosis assessment, applied in the fields of biotechnology and medicine, can solve the problems of lack of histological classification methods for breast cancer and cannot meet the needs of clinical diagnosis and treatment, and achieve the effect of high specificity, high sensitivity, and simple operation

Inactive Publication Date: 2015-07-29
JIAXING CITY NO 2 HOSPITAL
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Problems solved by technology

Breast cancer is a highly molecularly heterogeneous disease, and the traditional anatomical staging and histological classification can no longer meet its current clinical diagnosis and treatment needs, especially the lack ...

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  • Method for taking molecular marker in diagnosis and prognosis evaluation of breast cancer
  • Method for taking molecular marker in diagnosis and prognosis evaluation of breast cancer
  • Method for taking molecular marker in diagnosis and prognosis evaluation of breast cancer

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Embodiment Construction

[0020] The present invention will be further described in conjunction with the accompanying drawings and specific embodiments.

[0021] As shown in the figure, the concrete steps that the present invention implements are:

[0022] (1) Performing genotyping determination on subjects with breast cancer: obtaining test samples from subjects with breast cancer; determining the expression levels of S100A8 and S100A9 in the test samples; analyzing the relationship between expression levels and breast cancer genotyping Dependency:

[0023] From figure 1 It can be seen in A that the expression level of S100A8 is higher in Her2+ / basal-like breast cancer subjects, but lower in Luminal A / B breast cancer patients (Pfigure 1 In B, it can be seen that the expression level of S100A9 is higher in Her2+ / basal-like breast cancer subjects, but lower in Luminal A / B breast cancer patients (P<0.001).

[0024] (2) Prognostic assessment of subjects with breast cancer: According to breast cancer mic...

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Abstract

The invention relates to a method for taking the breast cancer molecular marker S100A8/A9 in diagnosis and prognosis evaluation of the breast cancer. According to the method, results show that the expression indexes of the molecular marker S100A8/A9 in breast cancer patients with different molecular pathological subtypes are different, that is, thesubtypemolecular marker S100A8/A9 is highly expressed in a substrate cellular type (basal-like) breast cancer patient and a Her-2 amplified) overexpression type breast cancer patient, but is relatively low in expression index in a lumen epithelia A type (Luminal A) breast cancer patient and a lumen epithelia B type (Luminal B) subtype breast cancer patient, that is, the statistic difference is obvious. For published NKI breast cancer chip data, patients are divided into a high group and a low group based on S100A8/A9 for Kaplan-Meier survivorship curve analysis, results show that the negative correlation between the S100A9 expression level and the total survival rate is obvious, the prognosis of a breast cancer patient with high S100A9 expression is poor, and the prognosis application value of prompting breast cancer is high.

Description

technical field [0001] The invention belongs to the field of biotechnology and medicine, and relates to a method for molecular markers for breast cancer diagnosis and prognosis assessment. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, accounting for 7-10% of all kinds of malignant tumors in the whole body, ranking first in the incidence of malignant tumors in women. In the past ten years, the incidence of breast cancer in my country has been increasing year by year, and the age of onset tends to be younger, which has seriously threatened the health of women in our country. Breast cancer is a highly molecularly heterogeneous disease, and the traditional anatomical staging and histological classification can no longer meet its current clinical diagnosis and treatment needs, especially the lack of breast cancer histological classification that can mark tumor biological behavior and provide guidance for clinical treatment met...

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 鲍轶王安涛莫娟芬郑丽
Owner JIAXING CITY NO 2 HOSPITAL
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