1,2,4‑Triazine derivatives for the treatment of viral infections
A compound and alkyl technology, applied in antiviral agents, drug combinations, allergic diseases, etc., can solve problems such as the complexity of innate immune model methods
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[0043] The preparation of formula (I) compound
[0044] Experimental part
[0045] 2 Preparation
[0046]
[0047] At room temperature, to 1 (20g, 176.9mmol, 1eq.) of H 2 Add Br to O (320mL) solution 2 (24mL, 466.8mmol, 2.6eq.). The mixture was stirred at 60 °C for 15 h, then NH 4 OH (50 mL). Then HCl (6N aq.) was added slowly until pH = 5, and the mixture was extracted with ethyl acetate (3 x 800 mL). The combined organic layers were washed with water and brine, dried (MgSO 4 ), the solids were removed by filtration, and the solvent of the filtrate was concentrated under reduced pressure to obtain 2 (16 g).
[0048] 1 H NMR (400MHz, DMSO-d 6 ): δppm 12.56(m,1H),12.31(m,1H)
[0049] 3 preparation
[0050]
[0051] At room temperature, to 2 (16g, 83.3mmol) of POCl 3 (80mL) solution was added PCl 5 (36.1 g, 173.4 mmol) and N,N-diethylaniline (35 mL, 221.7 mmol). The mixture was stirred at 120°C for 5 hours, then excess solvent was removed under reduced pressu...
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