A kind of pharmaceutical composition for treating diabetic encephalopathy and its preparation method and application
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A technology of diabetic encephalopathy and composition, which is applied in the field of pharmaceutical composition for the treatment of diabetic encephalopathy, and can solve problems such as lack of uniformity
Active Publication Date: 2018-08-03
CHENGDU HUASUN GRP INC LTD
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[0004] Diabetic encephalopathy is characterized by cognitive dysfunction, accompanied by a complication of structural and pathophysiological changes in the brain; some scholars have also proposed to name it "diabetes-related cognitive decline", which has not yet been unified
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Embodiment 1
[0049] The preparation of embodiment 1 pharmaceutical suspension oral liquid of the present invention
[0051] The experiment used water decoction, Pueraria 12g Coptidis 6g Scutellaria baicalensis 9g Dendrobium 12g was decocted in water and concentrated to a solution of 0.65g / ml, adding bear bile powder and Panax notoginseng powder to make a suspension.
Embodiment 2
[0052] The preparation of embodiment 2 pharmaceutical granules of the present invention
[0053] Take 12g of kudzu root, 6g of berberine, 9g of scutellaria baicalensis, 12g of dendrobium, 1.5g of bear bile, and 3g of notoginseng, extract according to the method in Example 1, concentrate, granulate, and granulate.
Embodiment 3
[0054] The preparation of embodiment 3 pharmaceutical capsules of the present invention
[0055] Pueraria 12g, Coptidis 6g, Scutellaria baicalensis 9g, Dendrobium 12g, bear bile 1.5g, Sanqi 3g were extracted according to the method of Example 1, concentrated, granulated, granulated, and packed into capsules.
[0056] Prove beneficial effect of the present invention by pharmacodynamic test below.
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Abstract
The invention provides a pharmaceutical composition for treating diabetic encephalopathy, which is a preparation prepared from the following raw materials in weight ratio: 12-18 parts of kudzu root, 8-12 parts of berberine, 8-12 parts of Scutellaria baicalensis, 12 parts of dendrobium ‑18 servings, 2‑4 servings of bear bile, 2‑4 servings of Panax notoginseng. The invention also provides the preparation method and application of the pharmaceutical composition. The drug of the present invention has obvious effect in preventing and treating diabetic encephalopathy, which is better than cilostazol, especially the middle dose group is the best. The medicine of the present invention protects microvessels (blood-brain barrier), promotes angiogenesis, improves hippocampal ischemia and hypoxia, and regulates the activity of hippocampal IGF‑1 and PI3K / AKT / CREB signaling pathways.
Description
technical field [0001] The invention relates to a pharmaceutical composition for treating diabetic encephalopathy, which belongs to the field of medicines. Background technique [0002] Diabetes (diabetes mellitus, DM) and its complications have become a health issue of public concern, because in recent years, with social and economic development, global diabetes patients have surged far beyond people's expectations, according to statistics from the International Diabetes Federation (IDF) In 2011, the number of diabetic patients in the world was 370 million, and developing countries accounted for 80% of the cases. The prevalence of diabetes in people over 20 years old in my country reached 9.7%, and China has become the country with the largest number of diabetic patients. Diabetes has a long course of disease, many complications, and high medical costs, which have a great impact on patients and society. At present, non-infectious diseases such as diabetes, tumors, and cardi...
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