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High-throughput automatic cleaning system for microarray chip and using method

A microarray chip, automatic cleaning technology, applied in the direction of using liquid cleaning methods, cleaning methods and utensils, chemical instruments and methods, etc. problems, to achieve the effect of reducing manual operation time, releasing labor, and high throughput

Active Publication Date: 2015-12-02
GENETEL PHARMA SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this microplate device is only suitable for adding and absorbing cleaning solution with a multi-channel pipette, because it does not have an adapter interface for an automatic plate washer, and cannot be adapted to an automatic plate washer to complete the cleaning of microarray chips

Method used

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  • High-throughput automatic cleaning system for microarray chip and using method
  • High-throughput automatic cleaning system for microarray chip and using method
  • High-throughput automatic cleaning system for microarray chip and using method

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specific Embodiment approach 1

[0044] like figure 1 As shown, the high-throughput automatic cleaning system for microarray chips includes 1—plate washer, 2—cleaning strips, and 3—microarray chips.

[0045] Among them, the cleaning slats are shaped like figure 2 As shown, there are 8 rows (A, B, C——H) and 12 columns (1, 2, 3——12) in total for 96 square hybridization wells in the cleaning plate; Figure 5 As shown, the opening size of each hole is 7.23×7.23mm, and the depth is 12.70mm;

[0046] like Image 6 As shown, the microarray chip is a nylon matrix film, the microarray chip is preferably a DNA microarray chip, the size of the microarray chip is 6.40×6.40mm, and the microarray chip is placed in the hole;

[0047] like image 3 As shown, a frame is designed on the bottom edge of the cleaning slat, which has the function of supporting the cleaning slat and connecting the cleaning slat to the tray of the plate washer; Figure 4 As shown, the frame is 125.70mm in length, width and height, 85.40mm, and 3...

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Abstract

The invention provides a high-throughput automatic cleaning system for a microarray chip. The system comprises a panel cleaning machine (1), a cleaning strip plate (2) and the microarray chip (3). A using method of the automatic cleaning system comprises the steps of (1) preparing all the components of the high-throughput automatic cleaning system for the microarray chip and assembling the components in sequence; (2) injecting liquid to enable the chip to suspend in the cleaning strip plate after liquid injecting; (3) performing vibratory cleaning; and (4) sucking liquid to enable the chip to be attached to the bottom of the cleaning strip plate after liquid sucking. The cleaning system and the using method have the advantages that the cleaning efficiency is high, cleaning pins have no direct contact with the chip in the whole process, damage is reduced, and manpower is saved.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a high-throughput automatic cleaning system for microarray chips and an application method thereof. Background technique [0002] A microarray chip refers to a micro-device set on a substrate in an array that can process and analyze biological or chemical information in a sample in parallel. The minimum distance between the centers of two adjacent points is based on the fact that no signal crossing occurs. [0003] Due to the small size of the microarray chip, the dot diameter is at the micron level, and in order to achieve high-density spotting, the dot pitch is often smaller than the dot diameter, the array size is at the millimeter level, the surface of the chip is mostly biological macromolecules, and the substrate material is nylon membrane glass, etc. Mainly, sensitive to mechanical damage. [0004] At present, there is an automatic cleaning system for the cleanin...

Claims

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Application Information

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IPC IPC(8): B08B3/08B08B3/10B08B13/00
CPCB08B3/08B08B3/10B08B13/00
Inventor 李勐赵雷黄明辉
Owner GENETEL PHARMA SHENZHEN
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