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Soft capsule for treating diseases of respiratory system

A technology for soft capsules and soft capsule preparations, applied in the field of pharmaceutical preparations, can solve problems such as unsuitable soft capsule dosage forms, oil leakage and the like

Inactive Publication Date: 2015-12-23
北京神州泰洁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1,8-Cineole is a monomer component of volatile oil, which is a volatile drug. The applicant once made this component into W / O or O / W emulsion-filled soft capsules, but oil leakage occurred after one week of storage Phenomena, indicating that it is not suitable to prepare soft capsule dosage form with other excipients except vegetable oil

Method used

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  • Soft capsule for treating diseases of respiratory system
  • Soft capsule for treating diseases of respiratory system
  • Soft capsule for treating diseases of respiratory system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1. Mix 100g of 1,8-cineole and 200g of sesame oil, and roll into 1000 soft capsules.

[0015] 2. Mix 50g of 1,8-cineole and 100g of sesame oil, and roll into 1000 soft capsules. .

[0016] 3. Mix 200g of 1,8-cineole and 100g of soybean oil, and roll them into 1000 soft capsules.

[0017] 4. Mix 200g of 1,8-cineole and 200g of sesame oil, and roll them into 1000 soft capsules.

[0018] 5. Mix 200g of 1,8-cineole and 400g of soybean oil, and roll them into 1000 soft capsules.

[0019] 6. In order to verify the impact of selected dosage forms and adjuvants on the stability of the preparation, the soft capsule prepared as adjuvant in Example 1 investigated the accelerated stability test for 6 months, and the results are shown in Table 1.

[0020] Table 1 Selected dosage forms and auxiliary materials on the impact results of preparation stability

[0021]

[0022] The results showed that the selected excipient sesame oil and soft capsule dosage form were suitable for ...

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Abstract

The invention discloses a soft capsule for treating diseases of a respiratory system. The soft capsule is mainly prepared from 1,8-cineole, and the contained substance can contain vegetable oil with a certain ratio. The soft capsule is used for treating the diseases of the respiratory system such as acute and chronic faucitis, rhinitis, asthma, obstructive (spastic) bronchitis, acute and chronic bronchitis, bronchiectasis, mucoviscidosis, cysticfibrosis and chronic obstructive pneumonia. The soft capsule has the advantages of being obvious in curative effect, convenient to use, high in safety and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a pharmaceutical preparation containing organic ingredients, in particular to a 1,8-cineole (C 10 h 18 O, Eucalyptol) as the main active ingredient in the form of soft capsules, which are suitable for the treatment of various respiratory diseases. Background technique [0002] Respiratory diseases are a serious threat to human life, especially respiratory infectious diseases are serious medical problems, accounting for 10% of morbidity and mortality, accounting for 75% of antibiotic use. Respiratory tract infection is divided into upper respiratory tract infection and lower respiratory tract infection. Upper respiratory tract infections include common cold, viral pharyngitis, laryngitis, herpetic angina, pharyngoconjunctival fever, bacterial pharyngotonsillitis, etc., 70% to 80% are caused by viruses, and another 20% to 30% are caused by viruses. The flu is c...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/352A61K47/44A61P11/00
Inventor 刘冬梅
Owner 北京神州泰洁生物科技有限公司
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