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Eslicarbazepine acetate and application method thereof

A technology for eslicarbazepine acetate and epilepsy, which is applied to eslicarbazepine acetate and its application fields, and can solve problems such as side effects and reduced efficacy of oxcarbazepine

Inactive Publication Date: 2015-12-30
BIAL PORTELA & CA SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, treatment with carbamazepine may cause serious side effects due to the production of toxic metabolites
Oxcarbazepine was developed to reduce the severity of those side effects, but oxcarbazepine has greatly reduced potency

Method used

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  • Eslicarbazepine acetate and application method thereof
  • Eslicarbazepine acetate and application method thereof
  • Eslicarbazepine acetate and application method thereof

Examples

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Embodiment Construction

[0016] The foregoing and following aspects and embodiments, including the studies discussed herein, have been described and illustrated by way of illustration only and should not be construed as limitations on scope.

[0017] One aspect of the present disclosure pertains to a method of treating at least one disease or condition in a patient in need thereof by administering a pharmaceutical composition comprising a pharmacologically effective amount of eslicarbazepine acetate.

[0018] In an exemplary embodiment of the present disclosure, the pharmaceutical composition comprising eslicarbazepine acetate is administered in a once-daily dosing regimen.

[0019] In another exemplary embodiment of the present disclosure, by exposure rate and exposure degree (C max and AUC 0-τ ) as a standard, the pharmaceutical composition is administered at a dose expected to maximize the total exposure to eslicarbazepine.

[0020] In an exemplary embodiment of the present disclosure, the at lea...

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PUM

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Abstract

The invention relates to a method for using eslicarbazepine acetate for treating various diseases and symptoms such as affective disorder, emotional schizophrenia, bipolar disorder, attention disorder, anxiety disorder, neuropathic pain, disorder related to neuropathic pain, sensorimotor dysfunction, vestibular disorder and neurological function alternation caused by retrogressive and post-ischemic diseases. The invention further relates to application of eslicarbazepine acetate to a method for reducing or relieving epileptic seizure of a patient, and a method for improving the exposing degree of eslicarbazepine acetate to a patient. The invention further relates to a method for preparing a medicine composition containing eslicarbazepine acetate.

Description

[0001] This application is a divisional application of the Chinese patent application No. 200580050978.8 with the filing date of May 6, 2005, and the title of the invention is "eslicarbazepine acetate and its application method". technical field [0002] The present disclosure relates to pharmaceutical compositions and methods of treatment using eslicarbazepine acetate. Background technique [0003] Carbamazepine is commonly used to treat epilepsy, pain disorders such as trigeminal neuralgia, and affective brain disorders such as bipolar disorder. However, treatment with carbamazepine may cause serious side effects due to the production of toxic metabolites. Oxcarbazepine was developed to reduce the severity of those side effects, but oxcarbazepine has greatly reduced potency. See, e.g., Almeida, L. & Soares-da-Silva, P., "Safety, Tolerability, and Pharmacokinetic Profile of BIA2-093, a Novel Putative Antiepileptic, ina Rising Multiple-Dose Study in Young Healthy Humans," J...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61P25/08A61K31/7048A61K31/19A61K31/53
Inventor P·M·维埃拉阿劳若苏亚雷斯达席尔瓦J·L·德阿尔梅达
Owner BIAL PORTELA & CA SA
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