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Application of antrodia camphorata compound in preparation of drugs for treating kidney diseases

A kidney disease and compound technology, which is applied in the field of application of Antrodia camphorata compounds in the preparation of drugs for the treatment of kidney diseases, and can solve the problems of uncontrollable immune response side effects, unclear effects, etc.

Inactive Publication Date: 2016-02-03
曾卉菱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although glucocorticoid steroid (glucocorticoid steroid) has been widely used in the treatment of IgAN patients, its effect on maintaining renal function and reducing proteinuria in IgAN is still unclear, and the potential uncontrollable immunosuppression caused by long-term use Side effects of reactions, still causing problems with medication

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  • Application of antrodia camphorata compound in preparation of drugs for treating kidney diseases
  • Application of antrodia camphorata compound in preparation of drugs for treating kidney diseases
  • Application of antrodia camphorata compound in preparation of drugs for treating kidney diseases

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Embodiment Construction

[0021] The present invention mainly aims at two compounds extracted from Antrodia camphorata, and detects whether they have the effect of treating kidney disease and resisting kidney inflammation. AntrocamolLT1 and AntrocamolLT2 are new compounds discovered by the inventors, and the above-mentioned extraction and structural identification data will be provided below.

[0022] Extraction of Antrodia Antrodia

[0023] Take Antrodia camphorata (Antrodiacamphorata) mycelia, fruiting bodies or a mixture of the two (1.0kg), extract twice with 10 times the amount of alcohol, combine and concentrate to obtain about 230g of crude extract (LT-E), crude extract with Dichloromethane / water (1:1) carried out the distribution extraction method 3 times, divided into about 102.6g of dichloromethane layer (LT-E-D) and about 127.4g of water layer (LT-E-W), and took 6.0g of dichloromethane layer It is separated into ANCA-E-D-1 and ANCA-E-D-2 by silica gel column chromatography through n-hexane / d...

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Abstract

The invention discloses application of an antrodia camphorata compound in preparation of drugs for treating kidney diseases. The compound is shown by a formula I as shown in the specification, and the kidney diseases can be glomerulosclerosis or post-streptococcal glomerulonephritis.

Description

technical field [0001] The invention relates to the medical application of a compound isolated from Antrodia camphorata, in particular to the application of an Antrodia camphorata compound in preparing medicine for treating kidney diseases. Background technique [0002] Antrodiacamphorata, also known as Antrodia camphorata, Antrodia camphorata, or Antrodia red, belongs to the perennial fungi of the order Aphyllophorales and the family Polyporaceae. It is a unique species of fungi in Taiwan and only grows in Taiwan. On the inner wall of the hollow decaying heartwood of the conservation tree species-Cinnamoumkanehirai Hay. Due to the extremely rare distribution of Cinnamomum camphora and human-made poaching, the number of wild Antrodia camphorata parasitic in it is even rarer, and because its fruiting body grows very slowly, the growth period is only between June and October. , and therefore very expensive. In Taiwanese folk medicine, Antrodia Cinnamomea has the functions of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P13/12A61P29/00
Inventor 张温良姚振文严逸钊曾卉菱曾宛平曾泰霖郭盈妤
Owner 曾卉菱
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