Pharmaceutical composition for treating diabetes type II
A technology for diabetes and composition, applied in the field of pharmaceutical compositions for the treatment of type II diabetes, can solve problems such as treatment methods without specific effects, and achieve remarkable effects
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[0020] The structural formula of the target compound is:
[0021]
[0022] Establishment of type 2 diabetes rat model
[0023] SPF grade male SD rats, body weight (140±10) g, feeding environment temperature is 20-25°C, relative humidity is 50%-60%, feeding 12 / 12h day and night. Routinely fed for 1 week, and then randomly divided into the normal group, 10 animals in the normal group were given normal feed, and other animals were given high-fat feed. The high-fat feed was purchased from Beijing Huafukang Biotechnology Co., Ltd., SCXK (Beijing) 2009-0004, and consisted of lard, egg yolk powder, sucrose, and basic maintenance feed.
[0024] Buffer solution preparation: prepare a citric acid-sodium citrate buffer solution with a pH of 4.4-4.6, about 1.07g citric acid and 1.44g sodium citrate per 100m1 buffer solution, store at 4°C for later use;
[0025] 1% streptozotocin (STZ) preparation: use the above buffer solution, prepare by dissolving 1g STZ in 100ml buffer solution, p...
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