Pharmaceutical composition for treating diabetes type II

A technology for diabetes and composition, applied in the field of pharmaceutical compositions for the treatment of type II diabetes, can solve problems such as treatment methods without specific effects, and achieve remarkable effects

Inactive Publication Date: 2016-02-03
辛衍雪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because its specific pathogenesis and pathological mechanism have not been fully elucidated, there is currently no effective treatment at home and abroad.

Method used

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  • Pharmaceutical composition for treating diabetes type II
  • Pharmaceutical composition for treating diabetes type II
  • Pharmaceutical composition for treating diabetes type II

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0020] The structural formula of the target compound is:

[0021]

[0022] Establishment of type 2 diabetes rat model

[0023] SPF grade male SD rats, body weight (140±10) g, feeding environment temperature is 20-25°C, relative humidity is 50%-60%, feeding 12 / 12h day and night. Routinely fed for 1 week, and then randomly divided into the normal group, 10 animals in the normal group were given normal feed, and other animals were given high-fat feed. The high-fat feed was purchased from Beijing Huafukang Biotechnology Co., Ltd., SCXK (Beijing) 2009-0004, and consisted of lard, egg yolk powder, sucrose, and basic maintenance feed.

[0024] Buffer solution preparation: prepare a citric acid-sodium citrate buffer solution with a pH of 4.4-4.6, about 1.07g citric acid and 1.44g sodium citrate per 100m1 buffer solution, store at 4°C for later use;

[0025] 1% streptozotocin (STZ) preparation: use the above buffer solution, prepare by dissolving 1g STZ in 100ml buffer solution, p...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating diabetes type II. The pharmaceutical composition contains an effective dose of compound and a pharmaceutically acceptable carrier, wherein the structure of the compound is as shown in the specification. The compound provided by the invention has an obvious effect on diabetes type II and can be developed into a new pharmaceutical composition which is effective clinically.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating type II diabetes. Background technique [0002] Diabetes is a common endocrine and metabolic disease. With the development of society and economy, changes in people's lifestyles and population aging, the incidence of diabetes is increasing year by year worldwide. It has become a disease after cardiovascular and tumors. , the third disease that threatens people's health and life. Diabetic microangiopathy (diabetic microangiopathy) is one of the most serious and common chronic complications of diabetes and one of the main causes of disability. How to use the advantages of traditional Chinese medicine to intervene in the process of diabetes, delay and treat the emergence of diabetic microangiopathy and other complications in time is a scientific and technological problem that needs to be solved urgently. [0003] Modern medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D217/16A61K31/472A61P3/10
CPCC07D217/16
Inventor 辛衍雪
Owner 辛衍雪
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