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Topical composition for preventing or reducing skin pigmentation and/or lightening skin tone and use thereof

A topical composition and compound technology, applied in skin care preparations, drug combinations, skin diseases, etc., can solve the problems of ascorbic acid instability, unpleasant smell and color, and easy oxidation

Active Publication Date: 2019-02-22
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, said whitening active ingredients have some disadvantages / disadvantages when applied in cosmetic compositions, for example: in most cosmetic compositions, ascorbic acid is unstable and easily oxidized; or when formulated in an effective dose, some botanical Extracts often produce unpleasant odors and colors in cosmetic compositions

Method used

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  • Topical composition for preventing or reducing skin pigmentation and/or lightening skin tone and use thereof
  • Topical composition for preventing or reducing skin pigmentation and/or lightening skin tone and use thereof
  • Topical composition for preventing or reducing skin pigmentation and/or lightening skin tone and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] Embodiment 1: preparation embodiment

[0151] The following examples were prepared (inv exp stands for inventive examples):

[0152]

[0153]

[0154] Above-mentioned embodiment is prepared according to the following steps:

[0155] 1. Add glycerin, propylene glycol, phenoxyethanol and sodium hydroxide to water at a temperature of 75°C and stir the mixture until homogeneous.

[0156] 2. Heat phase B to a temperature of 75°C, add phase B to phase A under turbine stirring; speed: 2000 rpm; machine brand: Turboptest™ 2004; supplier: VMI Turbotest.

[0157] 3. Cool the temperature of the mixture obtained in step 2 to 60°C, add phase C to the mixture under turbine stirring; speed: 2000 rpm; machine brand: Turboptest™ 2004; supplier: VMI Turbotest.

[0158] 4. Add phase D to the mixture obtained in step 3 at a temperature of 25°C, mixing the ingredients until homogeneous. Adjust the pH of phase D until a pH of 4.3 is reached.

Embodiment 2

[0159] Example 2: Evaluation Example

[0160] The examples were evaluated for their effectiveness in preventing or reducing skin pigmentation and / or lightening skin tone.

[0161] In vitro assay of normal human melanocytes was used to test the effect of Paeoniae officinalis root extract, the compound of formula (I) (wherein R 1 and R 3 for hydrogen, R 2 The depigmentation activity (reduction of melanin production) was measured as follows.

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Abstract

The present invention relates to a topical composition comprising the combination of the extract of a plant in the family Paeoniaceae and at least one compound of formula (I), and use thereof for preventing or decreasing skin pigmentation and / or lightening skin tone, wherein R, R 2 and R 3 are as defined in the specification.

Description

field of invention [0001] The present invention relates to a topical composition for preventing or reducing skin pigmentation and / or lightening skin tone. More specifically, the present invention relates to a topical composition comprising an extract of a plant of the family Paeoniae in combination with at least one compound of formula (I) according to the present application. The invention also relates to the use of the topical composition for preventing or reducing skin pigmentation and / or lightening the skin. Background of the invention [0002] Skin pigmentation control remains one of the key factors in achieving ideal skin in Asians. Although L’Oreal and other cosmetic companies have successfully developed a group of active ingredients with whitening effects, they cannot effectively meet the booming consumer demand for “natural origin ingredients” and the integration of traditional medicine. [0003] In the prior art, active ingredients having melanin production inhib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/67A61Q19/02A61P17/00
CPCA61K8/676A61K8/9789A61K31/375A61K36/65A61P17/00A61Q19/02A61K2300/00
Inventor 周亮S.约伊林L.鲍克斯J.塞尼
Owner LOREAL SA
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