Simulator model used for simulating tumor ultrasonic radiography

A technology of contrast-enhanced ultrasound and ultrasound contrast agent, which is applied in the field of phantom models, can solve the problems of distinguishing and unusable normal tissue models, and achieve the effects of easy acquisition, controllable consistency of finished products, and simple materials

Active Publication Date: 2016-03-02
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the above-mentioned phantoms are all models based on two-dimensional ultrasound imaging. Although the tumor model is hyperechoic in two-dimensional ultrasound imaging, it is still anechoic in harmonic contrast u

Method used

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  • Simulator model used for simulating tumor ultrasonic radiography
  • Simulator model used for simulating tumor ultrasonic radiography
  • Simulator model used for simulating tumor ultrasonic radiography

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0076] Example 1 Preparation of simulant model

[0077] Use an electronic balance to weigh 20g carrageenan and 1g stomach window acoustic contrast agent into a beaker, add 1000 mL of double distilled water, stir with a glass rod until uniform, heat, and place the beaker in a constant temperature water bath at 60°C to maintain the temperature. Form a normal tissue glue solution. Take 38 mL of normal tissue glue in a small beaker, add 2 mL of milk to form tumor glue Matrigel, then add lipid microbubble ultrasound contrast agent SonoVue (Bracco, Milan, Italy), stir evenly to form tumor glue. In this example, each bottle of SonoVue was dissolved in 6ml of physiological saline as mother liquor to prepare tumor glue models with SonoVue concentrations of 0.07%, 0.105%, 0.1225%, 0.14%, 0.175% and 0.21% (w / v). After placing the tumor glue in a sphere mold with a diameter of 3 cm, it was placed in ice water to quickly cool for 5 minutes, and the tumor glue model was obtained after taking ...

Example Embodiment

[0079] Example 2 Ultrasonic imaging effect detection of phantom model

[0080] The phantom models with different SonoVue concentrations were examined with contrast-enhanced ultrasound. In this embodiment, the phantom is detected with a clinical ultrasonic diagnostic instrument of Yum MyLabtwice model and a linear array probe LA332, the imaging frequency is 3-11MHz, the focus point is placed in the middle of the tumor, and the gain is 0.5. For the harmonic contrast ultrasound imaging mode, the mechanical index is 0.03 and the gain is 0.38. 10min after the phantom model is taken out of the refrigerator is defined as 0min, and the phantom model is subjected to two-dimensional ultrasound and harmonic contrast ultrasound imaging at different time points.

[0081] The result is figure 2 As shown, at the time point of 0 min, the phantom models prepared by SonoVue of different concentrations exhibit different imaging effects. When the concentration of SonoVue is low, the tumor glue and n...

Example Embodiment

[0086] Example 4 Temperature control for preparation of imitation model

[0087] When making the imitation model, the temperature of the solution is adjusted within a certain range of 50-70°C. As shown in Table 1. When the temperature is 50°C, the time for the echo of the tumor glue to fade away is the latest, but the solution is easy to solidify at this time, so the preferred temperature is about 60°, for example, 57-65°C. Trainers can adjust the temperature of the water bath according to their own needs and adjust accordingly.

[0088] Table 1. Tumor gel imaging time with different SonoVue content at different temperatures

[0089]

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Abstract

The invention relates to a simulator model used for simulating tumor ultrasonic radiography, comprising a tumor gum for simulating a tumor and a normal tissue gum for simulating the normal tissue around; the tumor gum shows high echo under a two dimension ultrasonic imaging mode and a harmonic wave ultrasonic imaging mode and then shows equal echo and no echo; and the normal tissues always shows the equal echo and no echo under the two dimension ultrasonic imaging mode and the harmonic wave ultrasonic imaging mode. The simulator can simulate the acoustics characteristics of the liver cancer under the ultrasonic radiography, which benefits the usage of the ultrasonic radiography scanning method and the exercise of tumor puncture biopsy and tumor ablation treatment under the guiding of the ultrasonic wave.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a phantom model for simulating cancer contrast-enhanced ultrasound. Specifically, it relates to the fields of contrast-enhanced ultrasound and ultrasound-guided liver cancer diagnosis and interventional therapy in ultrasound medicine, and relates to a teaching and training model for contrast-enhanced ultrasound technology, ultrasound-guided puncture biopsy technology, tumor ablation and curative effect evaluation. technical background [0002] The contrast-enhanced ultrasound technology is considered to be the third revolution in the development of ultrasound medicine, which advances the diagnostic mode of ultrasound from conventional morphological diagnosis to functional diagnosis. In 2013, after in-depth analysis of a large number of prospective clinical studies, Westwood et al. proposed that the diagnostic efficiency of contrast-enhanced ultrasound technology for focal liver lesions is co...

Claims

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Application Information

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IPC IPC(8): G09B23/28
CPCG09B23/286
Inventor 苏中振周慧超吕淑敏许尔蛟李凯郑荣琴
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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