Protein interaction network construction method

An interaction network and protein technology, which is applied in the field of protein interaction network construction, can solve the problems of data redundancy, false positive, difficult to use protein interaction information, protein interaction information lag, etc., and achieve novel ideas

Inactive Publication Date: 2016-03-09
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, due to data redundancy and high false positives among various databases, it is difficult to effectively use the protein interaction information stored in a single protein database.
In addition, due to the different d

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be further described below in conjunction with specific embodiments, and the exemplary embodiments of the present invention can be used to explain the present invention, but are not intended to limit the present invention.

[0021] Let's take a protein as an example to further explain

[0022] Protein type: CD147 is a cell surface glycoprotein that belongs to the immunoglobulin superfamily.

[0023] Step 1: Use human proteins stored in HPRD, DIP, Reactome, IntAct, MINT, SPIKE and BioGrid databases as proteins of interest and construct a protein set A of interest;

[0024] Step 2: Taking CD147 in protein set A of interest as the target protein, extract all CD147-protein interactions from HPRD, DIP, Reactome, IntAct, MINT, SPIKE and BioGrid databases;

[0025] Step 3: Use the MySQL database to integrate the CD147-protein interaction information in step 2, remove redundant CD147-protein interaction relationships in multiple databases, and constr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses a protein interaction network construction method. The method comprises the following steps: acquiring a protein set that is interested in; constructing a first-level interaction protein database of a target protein, and drawing a first-level protein interaction network of the target protein according to the first-level interaction protein database; and constructing a second-level interaction protein database of the target protein, and in conjunction with the first-level protein interaction network of the target protein, drawing an interaction protein database of the target protein. Compared with the prior art, according to the method disclosed by the present invention the candidate database used when constructing the protein interaction network is comprehensive and extensive, and the idea of integrated use and expanded application of an existing database is novel; the protein interaction database can comprehensively and extensively store existing protein interaction relationships, the source is reliable, and the query is convenient; and a reliable basis is provided for experimental verification of unknown protein functions.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method for constructing a protein interaction network. Background technique [0002] With the continuous supplement of human protein data, more and more unknown functions of proteins need to be discovered for biomedical research. Most proteins must be combined with other proteins or biomacromolecules to perform their functions. Therefore, to study protein functions, it is necessary to clarify the information of the proteins that interact with them. And based on the function of interacting proteins, speculate and verify the role of the target protein in cell function and biological process. At present, there are many high-throughput methods for identifying protein interactions, and they are stored in different protein databases. The existing protein interaction databases are as follows: [0003] 1. HPRD (HumanProteinReferenceDatabase) only collects human protein interaction (PPI)...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G06F19/28
CPCG16B50/00
Inventor 朱平张葵郑艳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap