Unlock instant, AI-driven research and patent intelligence for your innovation.

A new phenylpropanoid glycoside compound and its preparation method and application

A new technology of phenylpropanoid glycosides and compounds, applied in the field of phytochemistry, to achieve simple extraction and separation methods, inhibition of tumor cell growth, and good curative effect

Inactive Publication Date: 2017-12-08
NANYANG NORMAL UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results show that the compound has a certain anti-tumor activity, so far there is no relevant literature or patent report on the structure and activity of the compound at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A new phenylpropanoid glycoside compound and its preparation method and application
  • A new phenylpropanoid glycoside compound and its preparation method and application
  • A new phenylpropanoid glycoside compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention is a new phenylpropanoid glycoside compound, the chemical name is: 5"-hydroxymethyl-1"-1-[9-(3', 5'-dimethoxy-4'-hydroxyphenoxy) -propenyl]-3,5-dimethoxy-phenoxy-tetrahydro-pyran-2",3",4"-triol, the structure of the compound is shown in the figure below:

[0018]

[0019] The compound is a new compound isolated from thistle plant of the genus Asteraceae.

[0020] The preparation of above-mentioned compound I:

[0021] The preparation method of the present invention comprises the following steps: take 12.5 kilograms of dry above-ground parts of thistle as raw material, extract 3 times with 95% ethanol (18 L×3), each time for 2 hours, and concentrate under low temperature and reduced pressure to obtain thick paste 1.4 kilogram. The thick paste was suspended in water, and extracted successively with petroleum ether, ethyl acetate and n-butanol to obtain 99.6 grams of petroleum ether, 210.4 grams of ethyl acetate and 294.5 grams of n-butanol, resp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a new phenylpropanoid glycoside compound extracted and separated from cirsium japonicum and a preparation method thereof, and further relates to anti-tumor application of the compound. The compound has a chemical name of 5'-hydroxymethy-1'-1-[9-(3',5'-dimethoxy-4'-hydroxyphenoxy)-propeny]-3,5-dimethoxy-phenoxy-tetrahydro-pyran-2',3',4'-triol, and can be applied to preparation of anti-tumor medicines. The new phenylpropanoid glycoside compound has the advantages of novel structure and tumor cell growth inhibiting activity and simple extraction and separation method, is convenient for further pharmacological and clinical researches, and establishes an important theoretical basis for development of novel anti-tumor medicines with good curative effect and small toxic and side effect.

Description

technical field [0001] The invention belongs to the field of phytochemistry, and in particular relates to a novel phenylpropanoid glycoside compound extracted and separated from Cirsium japonicum and a preparation method thereof; the invention also relates to the antitumor application of the compound. Background technique [0002] Cirsium japonicum (Cirsium japonicum) is a plant of the genus Thistle in the Asteraceae family. It is a perennial herb with erect stems, fine longitudinal stripes, and white filamentous hairs at the base. It is widely distributed throughout my country. Thistle is cool in nature, sweet in the mouth, bitter in the mouth, returns to heart, Liver meridian, and effect is cooling blood to stop bleeding, dispelling blood stasis, detoxifying and eliminating carbuncle. Modern literature reports that thistle contains flavonoids and flavonoid glycosides, long-chain (en) acetylenic alcohols, volatile oils, triterpenes, sterols and other chemical components. I...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/203C07H1/08A61P35/00
CPCC07H1/08C07H15/203
Inventor 马勤阁张正辉张新刚魏荣锐柳文敏雷晓玲杨晶晶葛晓林张爽
Owner NANYANG NORMAL UNIV