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58results about How to "Simple extraction and separation method" patented technology
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Total toadpoison lactones extraction with anti-tumor function, preparation and application thereof
ActiveCN101209264AHigh purityImprove clinical efficacyAmphibian material medical ingredientsOrganic active ingredientsChromatographic separationClinical efficacy
The invention discloses a total bufogenin extract with antitumor function and also discloses a preparation method of the extract and application thereof in the preparation of antitumor medicines. The total bufogenin extract of the invention is prepared by organic solvent extraction, column chromatography separation and purification of dried toadskin; the content of total bufogenin is over 80 percent, wherein the content of resibufogenin is over 12 percent, the content of cinobufagin is over 4 percent, and the content of bufotalin is over 10 percent. Compared with the prior art, the invention eliminates bufotenine alkaloid which has irritation, is easy to cause hypersensitivity but has no antitumor activity, efficiently collects the effective part of total bufogenin which has significant antitumor activity, therefore pharmacological action is stronger, the clinical curative effect is higher and the toxic and side effect is lower. The total bufogenin extract can be prepared into various pharmaceutical preparations for clinical application, therefore the invention has the functions of killing tumor cells, inducing differentiation and apoptosis of tumor cells, inhibiting the neovascularization of tumor cells and lowering the neoplasm metastasis rate, etc.
Owner:吴宗好
Marine fungus-derived polyketone compound and application thereof in treatment of type 2 diabetes
ActiveCN104987316ASimple extraction and separation methodLow costOrganic chemistryMetabolism disorderDrug compoundMicrobiology
The invention belongs to the field of medicinal compounds, and concretely discloses a marine fungus-derived polyketone compound, a preparation method thereof, and an application thereof in treatment of type 2 diabetes. The structure of the polyketone compound is represented by formula (I). The compound can substantially inhibit the activity of alpha-glucosidase, and the IC50 value of the compound is (9.05+ / -0.60)[mu]M. Enzyme kinetic researches show that the compound is a typical noncompetitive inhibitor. The compound can be used for preparing alpha-glucosidase inhibitor medicines in order to prevent and treat the type 2 diabetes.
Owner:SUN YAT SEN UNIV
Method for extracting euscaphis konishii hayata high-efficiency anti-inflammatory action compound and product
ActiveCN104274502ASimple extraction and separation methodThe extraction and separation method is practicalAntipyreticAnalgesicsAnti-inflammatoryChemistry
The invention relates to a method for extracting a euscaphis konishii hayata high-efficiency anti-inflammatory action compound and a product. The method mainly comprises the following steps: taking a euscaphis konishii hayata plant, chopping, drying at the temperature of 50 DEG C and grinding; taking the plant powder, condensing and performing reflux extraction for three times by using distilled water, wherein the extraction time is 3 hours each time; filtering and merging so as to obtain the filtrate, extracting the filtrate by using n-butyl alcohol, extracting for three times, merging the n-butyl alcohol extracting solution, performing rotary evaporation and concentration, thereby obtaining the extract S, namely, the product provided by the invention. The extraction and separation method is simple and rich in resources, the extract is obvious in effects of diminishing inflammation and inhibiting capillary permeability, and the effects of the extract are obviously higher than those of dexamethasone injection.
Owner:福建药一制药有限公司
Novel triterpenoid compound and preparation method thereof
InactiveCN102267891ANovel structureSimple extraction and separation methodAntineoplastic agentsAnhydride/acid/halide active ingredientsChemical structureTriterpene
The invention relates to a novel triterpenoid compound extracted and separated from Kadsura coccinea roots and application thereof in preparation of human acute promyelocytic leukemia cell line HL-60 inhibitors. The compound has a chemical structure formula shown in a formula I. The experimental study shows that the compound has growth inhibition action on human acute promyelocytic leukemia cell line HL-60, and the extraction and separation method of the compound is simple, thereby facilitating the further pharmacological and clinical research of the compound and the development of the application of the compound in preparation of antitumor drugs. The formula I is shown in the specification.
Owner:SHENYANG PHARMA UNIVERSITY
Steroid saponin type compound as well as preparation method and application of steroid saponin type compound
ActiveCN106749492ANovel structureSimple extraction and separation methodOrganic active ingredientsAntipyreticMouse MonocyteClinical research
The invention belongs to the technical field of medicines, and relates to a new steroid saponin type compound extracted and separated out from roots and tubers of trillium tschonoskii, and application of the new steroid saponin type compound to preparation of an inflammatory cell inhibitor. The compound has a chemical structural formula shown as a formula I; an experiment result shows that the new steroid saponin type compound can be used for inhibiting generation of an inflammatory mediator NO in mouse monocyte-macrophages RAW264.7 under the stimulation of LPS (Lipopolysaccharide); a preparation method of the compound is simple and easy, and further pharmacological and clinical researches are easy to carry out; the application of the new steroid saponin type compound in anti-inflammatory drugs is developed. (The formula I is shown in the description.).
Owner:SHENYANG PHARMA UNIVERSITY
Anemarrhena asphodeloides bge steroid saponin compound, and preparation method and application thereof
ActiveCN110627861ANovel structureSimple extraction and separation methodOrganic active ingredientsSteroidsSilica gelHuman breast
The invention discloses an anemarrhena asphodeloides bge steroid saponin compound, and a preparation method and an application thereof in preparation of an antitumor drug. The compound is spirostanolsteroid saponin, the molecular formula of the compound is C45H74O17, and the molecular weight of the compound is 886. The compound is prepared by extracting medicinal plant anemarrhena asphodeloides bge with 75% ethanol, extracting with water-saturated n-butyl alcohol, and separating and purifying by macroporous adsorption resin, silica gel column chromatography, ODS reversed-phase column chromatography, gel column chromatography and other methods. MTT experimental results show that the compound has remarkable anti-tumor activity on human breast cancer cell strains (MCF-7) and human liver cancer cell strains (HepG2), and is expected to become an anti-tumor candidate drug.
Owner:CHINA PHARM UNIV
Eucommia ulmoides extract and application thereof in treatment of osteoporosis
InactiveCN111686147ASimple extraction and separation methodGood effectSkeletal disorderNatural extract food ingredientsOsteoporosisEthanol extracts
The invention provides eucommia ulmoides extract and an application thereof in treatment of osteoporosis, and belongs to the technical field of traditional Chinese medicine extraction. The eucommia ulmoides extract comprises the following components in parts by weight: 20-50 parts of eucommia ulmoides petroleum ether extract and 10-30 parts of eucommia ulmoides ethanol extract; the eucommia ulmoides extract can be effectively used for treating the osteoporosis by controlling the weight part ratio of the eucommia ulmoides petroleum ether extract to the eucommia ulmoides ethanol extract to be (1-5): 1. The invention further provides an extraction method of the eucommia ulmoides petroleum ether extract and the eucommia ulmoides ethanol extract. Due to the fact that different effective components are different in solubility in different solvents, the content of the effective components can be effectively adjusted by adopting different solvents for extraction; the used extraction separationmethod is simple and easy to implement; and the osteoporosis treating effect is good.
Owner:JIANGXI POZIN PHARMA
Three novel compounds in paeonia anomala and healthcare and medical applications of compounds
InactiveCN108191931AClarify the relationship between the active ingredientsNeuroprotectiveNervous disorderSugar derivativesChromatographic columnNeuroprotective factors
The invention relates to the technical field of food and traditional Chinese medicines and provides a preparation method and applications of three novel compounds extracted and separated from paeoniaanomala. Chemical structural formulas of the compounds are shown in formulas (I), (II) and (III). Dried root tubers of paeonia anomala are crushed and then subjected to heating reflux extraction with80% ethanol, a total extract obtained through reduced pressure concentration is dispersed with water, extraction is performed with petroleum ether, ethyl acetate and water-saturated n-butyl alcohol with the same volume respectively, and parts are obtained. The n-butyl alcohol part is dissolved with water, macroporous resin column chromatography is performed, and fractions are obtained; the 30% ethanol part is separated and purified through silica gel column chromatography, a target chromatographic liquid is collected, separation with a C18 reversed phase chromatographic column and purificationwith Sephadex LH-20 (hydroxypropyl sephadex) are performed, and the compounds I, II and III are obtained. The invention also provides applications of the three compounds in neuroprotection and neurodegenerative disease treatment.
Owner:CHINA PHARM UNIV
New application of cardiac glycoside compound
ActiveCN103191143AGood antitumor activityThe separation method is simpleOrganic active ingredientsSteroidsLead compoundChemical compound
The invention discloses an application of a cardiac glycoside compound 12 beta-hydroxycalotropin in preparing medicines for treating and preventing tumors. The cardiac glycoside compound 12 beta-hydroxycalotropin has obvious antitumor activity and can be served as a lead compound for treating the tumors. Moreover, an extraction and separation method of the cardiac glycoside compound 12 beta-hydroxycalotropin provided by the invention is simple and practicable and low in cost, and has high efficiency and yield and good extract quality.
Owner:TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
New application of hydroquinone compound
InactiveCN102048716ASignificant anti-HCV activitySimple extraction and separation methodOrganic active ingredientsQuinone separation/purificationHcv hepatitis c virusHydroquinone Compound
The invention relates to new application of a hydroquinone compound, particularly application of a hydroquinone compound (shikonin) in preparing medicines for resisting hepatitis C virus (HCV). The hydroquinone compound (shikonin) has obvious activity for resisting HCV, and the selection index is up to 43.56; and thus, the hydroquinone compound (shikonin) can be used as a lead compound for treating hepatitis C. The molecular formula of the hydroquinone compound (shikonin) is C16H16O5, and the chemical structural formula is disclosed in the specification.
Owner:KUNMING UNIV OF SCI & TECH
3,4-ring-opening polyacylation grayananes diterpene compound and preparation method thereof
InactiveCN101648932ANovel structureThe separation method is simpleOrganic chemistryDiterpeneStructural formula
The invention provides a novel 3,4-ring-opening polyacylation grayananes diterpene compound and also relates to a method for extracting and separating the 3,4-ring-opening polyacylation grayananes diterpene compound from Pieris Formosa. The obtained compound is determined as 3,4-seco-3,10-olide-5beta-hydroxy-6beta,7alpha, 11alpha,15alpha,16alpha-pentaacetoxy-14beta-propionyloxygrayan-4(19)-ene through structural identification and is called as pieris formosin E(1), and 3,4-ring-opening polyacylation grayananes diterpene which is discovered for the first time has the structural formula.
Owner:KUNMING UNIV OF SCI & TECH
Marine fungus-derived depside compounds and application thereof in treatment of type 2 diabetes
ActiveCN104987319AInhibitory activitySimple extraction and separation methodOrganic chemistryMetabolism disorderAlgluceraseChemistry
The invention belongs to the field of medicinal compounds, and concretely discloses marine fungus-derived depside compounds and an application thereof in treatment of type 2 diabetes. The structure of the depside compounds is represented by formula (I). The compounds 1-6 can substantially inhibit the activity of alpha-glucosidase, the IC50 value of the compound 1 is 10.4[mu]M, the IC50 value of the compound 2 is 13.3[mu]M, the IC50 value of the compound 3 is 2.1[mu]M, the IC50 value of the compound 4 is 12.4[mu]M, the IC50 value of the compound 5 is 9.8[mu]M, and the IC50 value of the compound 6 is 11.7[mu]M, wherein the IC50 value of positive control acarbose is 553.7[mu]M. Kinetic researches of the alpha-glucosidaseinhibition effect show that the compounds 1, 3 and 5 are noncompetitive inhibitors. The compounds can be used for preparing alpha-glucosidase inhibitor medicines in order to prevent and treat the type 2 diabetes.
Owner:SUN YAT SEN UNIV
Chloric biphenyl cyclooctene lignan compounds and preparation thereof
InactiveCN101503401ANovel structureSimple extraction and separation methodOrganic chemistryLignanStructural formula
The invention relates to a novel compound, in particular to a chlorine-containing biphenyl cyclooctene-class lignan compound. The invention also relates to a method for extracting the chlorine-containing biphenyl cyclooctene-class lignan compound from Schisandra sphenanthera fruit. According to structural identification, an isolated substance obtained from the extraction has biphenyl cyclooctene-class lignan which is substituted by chloromethyl on an octatomic ring. Such phenomenon is discovered in advanced plants for the first time. The molecular formula of the isolated substance is C28H33O9Cl and is named chloromethyl schisantherin B which has the above structural formula.
Owner:KUNMING UNIV OF SCI & TECH
Total toadpoison lactones extraction with anti-tumor function, preparation and application thereof
ActiveCN101209264BHigh purityImprove clinical efficacyAmphibian material medical ingredientsOrganic active ingredientsChromatographic separationLymphatic Spread
The invention discloses a total bufogenin extract with antitumor function and also discloses a preparation method of the extract and application thereof in the preparation of antitumor medicines. The total bufogenin extract of the invention is prepared by organic solvent extraction, column chromatography separation and purification of dried toadskin; the content of total bufogenin is over 80 percent, wherein the content of resibufogenin is over 12 percent, the content of cinobufagin is over 4 percent, and the content of bufotalin is over 10 percent. Compared with the prior art, the invention eliminates bufotenine alkaloid which has irritation, is easy to cause hypersensitivity but has no antitumor activity, efficiently collects the effective part of total bufogenin which has significant antitumor activity, therefore pharmacological action is stronger, the clinical curative effect is higher and the toxic and side effect is lower. The total bufogenin extract can be prepared into variouspharmaceutical preparations for clinical application, therefore the invention has the functions of killing tumor cells, inducing differentiation and apoptosis of tumor cells, inhibiting the neovascularization of tumor cells and lowering the neoplasm metastasis rate, etc.
Owner:吴宗好
Alkynyl glycoside compound and extraction and separation method and application thereof
ActiveCN106939028ASimple extraction and separation methodEfficient extraction and separation methodsOrganic active ingredientsSugar derivativesGradient elutionEthyl acetate
The invention relates to an alkynyl glycoside compound and an extraction and separation method and an application thereof, and belongs to the field of extraction and separation of natural compounds. The extraction and separation method comprises the steps: carrying out ultrasonic extraction of a patycodon grandiflorum powder, and concentrating the extract liquid to obtain a first extractum; adding water to the first extractum, dissolving, then adding to adsorption resin, carrying out gradient elution with ethanol, and concentrating the eluate of gradient elution for a second time to obtain a second extractum; carrying out countercurrent chromatography separation and purification of the second extractum with a solvent system of n-hexane, ethyl acetate, methanol and water with a volume ratio of 1:(28-32):1:(28-32), and collecting polyacetylene compound effluent; and concentrating the polyacetylene compound effluent for a third time, and preparing with a high performance liquid chromatograph and with acetonitrile-water as a mobile phase. The method is efficient and fast; and the purified alkynyl glycoside compound has antimicrobial and antitumor activities and the like, and can be applied to preparation of anti-biological toxicity drugs.
Owner:INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
Use of cardiac glycoside compound
ActiveCN104324043AGood antitumor activitySimple extraction and separation methodOrganic active ingredientsSteroidsLead compoundDrug
The invention discloses the use of cardiac glycoside compound 12 beta-hydroxycalotropin in preparing medicines having tumor treating and preventing effects. The cardiac glycoside compound 12 beta-hydroxycalotropin has remarkable anti-tumor activity and is capable of serving as a lead compound for treating tumors; meanwhile, a method for extracting and separating the cardiac glycoside compound 12 beta-hydroxycalotropin provided by the invention is simple, feasible, low in cost, and high in efficiency and yield; the extract is good in quality.
Owner:TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
Preparation method for separating lysozyme by amino-functionalized magnetic nanoparticles
InactiveCN105268416ALarge specific surface areaReduce the impactOther chemical processesEnzymesMagnetite NanoparticlesRefrigerated temperature
The invention discloses a preparation method of separating lysozyme by amino-functionalized magnetic nanoparticles and specifically designs a method for separating lysozyme from egg white by the use of a magnetic nanoparticles adsorption material. According to the preparation method, Fe3O4 nanoparticles are selected and undergo surface-amino functionization modification so as to obtain amino-functionalized magnetic nanoparticles; the nanoparticles are added into an egg white solution and are saturated after 1 h of adsorption at 37 DEG C; the amino-functionalized magnetic nanoparticles saturated by adsorption are added into a phosphate buffer (20 nmol, pH=8.0, 1 mol / L NaCl) to be eluted at 37 DEG C for 2 h; and magnetic separation is carried out to obtain a solution, the eluate is put into a refrigerator of 4 DEG C, and centrifugation is carried out to obtain a solid enzyme powder. The separation method for extraction of egg white lysozyme is simple and has high separation efficiency. The obtained lysozyme has high purity. In addition, conditions are mild and have little influence on lysozyme activity, and recovery rate is high.
Owner:JILIN UNIV
Method for back extraction of cobalt by utilizing microfluidics technology
InactiveCN108359811AIncrease interface areaExcellent mixed mass transfer performanceProcess efficiency improvementMicroreactorMicrofluidics
The invention relates to a method for back extraction of cobalt by utilizing a microfluidics technology, and belongs to the technical field of hydrometallurgy. In the method, a hydrochloric acid or sulfuric acid solution is used as a back-extractant to form a water phase A, cobalt ion organic extraction liquid is used as an oil phase A, and the water phase A and the oil phase A are respectively introduced into a T-shaped or Y-shaped microreactor to carry out back extracting reaction; products are collected at an outlet of the T-shaped or Y-shaped microreactor and a water phase B and an organicphase B are obtained after standing and phase-separating, proton exchange reaction between CO2+ and H+ is carried out to enter the water phase B, and an organic extractant remains in the organic phase B. The method utilizes the advantages of short mass transfer distance, high mass transfer efficiency and the like of the microfluidics technology to realize high-efficiency back extraction of cobalt.
Owner:KUNMING UNIV OF SCI & TECH
Tetrahydroxanthone dimer compound as well as preparation method and application thereof
The invention discloses a tetrahydro-oxanthone dimer compound as shown in a formula (I), a preparation method of the tetrahydro-oxanthone dimer compound and application of the tetrahydro-oxanthone dimer compound to preparation of antibacterial agents, talaromyces sp. WHUF0362 screened by the invention is convenient to culture and easy to survive, the compound (I) extracted by fermentation of the talaromyces sp. WHUF0362 has a certain inhibition effect on helicobacter pylori, the MIC (minimal inhibitory concentration) value reaches 0.125 mu g / mL, and the compound can be used for preparing antibacterial agents. The extraction and separation method is simple and easy, further pharmacological and clinical research is facilitated, and conditions are created for developing novel antibacterial drugs with good curative effects and small toxic and side effects.
Owner:ZHEJIANG UNIV OF TECH +1
Method for purifying quercetin glucoside in semen lepidii
ActiveCN113150052AIncrease contentSimple extraction and separation methodSugar derivativesOrganic chemistry methodsGlycosideFluid phase
The invention discloses a method for purifying quercetin glucoside in semen lepidii. The method is characterized by comprising the following steps of (1) carrying out primary water extraction on quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside in the semen lepidii; (2) performing alcohol precipitation and impurity removal on the semen lepidii water extract; (3) eluting and separating by using LX-68G type macroporous resin; (4) eluting and purifying with a CM-agarose gel FF column; and (5) carrying out preparative liquid phase purification, so as to obtain a quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside monomeric compound. Experimental results show that the CM-agarose gel FF has a good purification effect on quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside, the purity of a sample subjected to preparative liquid phase separation and purification can reach 99.0% or above, the technical requirement that the purity of the sample is larger than 98.5% of a national traditional Chinese medicine reference substance is met, and the obtained product can be used as the traditional Chinese medicine reference substance.
Owner:YANTAI UNIV
Novel triterpene compound of C3,4 split ring and preparation method thereof
InactiveCN102276466BNovel structureSimple extraction and separation methodOrganic active ingredientsOrganic compound preparationExperimental researchTriterpene
The invention relates to a novel triterpene compound extracted and separated from rosy south fructus schisandrae root and application of the compound to preparing of inhibitors of human promyelotic leukemia cell lines HL-60. The compound has a structure as shown in the formula I described in the specification. Experimental researches show that the compound has the growth inhibition action on the human promyelotic leukemia cell lines HL-60. Furthermore, a method for extracting and separating the compound is simple and easy; and the method is advantageous for carrying out further pharmacology and clinical research and developing the application of the compound to preparing of anti-tumour drugs.
Owner:SHENYANG PHARMA UNIVERSITY
Plant extracts with antitumor activity and active ingredients thereof
InactiveCN103450314BCytotoxicGood antitumor activityOrganic active ingredientsSteroids preparationSide effectBuxus
Owner:SHENYANG PHARMA UNIVERSITY
Juglans mandshurica bark extract and application thereof in preparing anticancer drugs
ActiveCN102274279BGood effectSimple extraction and separation methodAntineoplastic agentsPlant ingredientsEthyl acetateCancer resistance
Owner:GUANGDONG PHARMA UNIV
Alkynidine glycosides and their extraction and separation methods and applications
ActiveCN106939028BSimple extraction and separation methodEfficient extraction and separation methodsOrganic active ingredientsSugar derivativesGradient elutionEthyl acetate
The invention relates to alkyne glycoside compounds and their extraction and separation method and application, belonging to the field of extraction and separation of natural compounds. The extraction and separation method is to ultrasonically extract the powder of Platycodon grandiflorum with methanol, and concentrate the extract to obtain the first extract; the first extract Add water to dissolve and add to the adsorption resin to carry out gradient elution with ethanol, and concentrate the eluent of gradient elution for the second time to obtain the second extract; the volume ratio of the second extract is 1:28-32:1:28 The solvent system of n-hexane, ethyl acetate, methanol and water of ‑32 is subjected to countercurrent chromatographic separation and purification, and the polyalkyne component effluent is collected; after the polyacetylene component effluent is concentrated for the third time, use high-performance liquid chromatography to obtain Acetonitrile-water is used as the mobile phase for preparation; the method is efficient and fast, and the purified alkyne glycoside compounds have antimicrobial, antitumor and other activities, and can be applied to the preparation of antibiotoxic drugs.
Owner:INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
Polycyclic polyisopentenyl acyl phloroglucinol compound and its preparation method and application
ActiveCN110511202BEasy to getSimple extraction and separation methodOrganic chemistryAntineoplastic agentsAcyl groupDrug target
The polycyclic polyisopentenyl acylphloroglucinol compound and its preparation method and application relate to the technical field of medicine. It is obtained from the whole stem of the plant. The extraction and separation method is simple and the raw materials are easy to obtain. The polycyclic polyisopentenyl acylphloroglucinol compound is used in the preparation of antitumor drugs, and can be used as an anticancer drug targeting nuclear receptor RXRα. It can target the nuclear receptor RXRα to inhibit the proliferation of human breast cancer cell line (MCF‑7) and cervical cancer cell line (HeLa). Therefore, the compound is expected to be developed as an anti-tumor drug targeting the nuclear receptor RXRα or as a lead compound for the development of an anti-tumor drug.
Owner:XIAMEN UNIV
Aryl dihydronaphthalene lignan compound as well as preparation method and application thereof
ActiveCN114262270AGet strongSimple extraction and separation methodCarboxylic acid esters separation/purificationAntineoplastic agentsChemical synthesisLignan
The invention discloses an aryl dihydronaphthalene lignan compound with antineoplastic activity and a preparation method and application thereof, the aryl dihydronaphthalene lignan compound has the following structural general formula and belongs to the technical field of medicine, and the compound is extracted and separated from dry rhizome of rhizoma drynariae. Meanwhile, the compound 1 is prepared from 12-hydroxylauric acid through methylation reaction, esterification reaction and oxidative coupling reaction; the compound 2 is prepared by carrying out oxidative coupling reaction on a known compound glycyl 12-caffeoyloxane obtained by separation, and the compound 2 is prepared by carrying out oxidative coupling reaction on the known compound glycyl 12-caffeoyloxane; the compound disclosed by the invention can be obtained through extraction separation and can also be obtained through chemical synthesis; the compounds 1 and 2 disclosed by the invention have very strong selective inhibition activity on a human cervical cancer HeLa cell strain.
Owner:THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
A kind of alkaloid compound, preparation method and application
The present invention belongs to natural extraction compounds and their preparation methods and applications. Although there are many types of existing hypoglycemic drugs, they still have large side effects, poor curative effect on complications, and drug resistance is prone to appear with prolonged medication time. Technical problem, provide a kind of alkaloid compound, preparation method and application, the molecular formula of alkaloid compound is C 46 h 63 N 3 o 23 , is an indole glycoside dimer alkaloid, and the preparation method includes extracting the total extract from Jiuzilian, extracting the total extract, and performing column chromatography separation on the n-butanol extraction layer. The preparation method is simple and effective to obtain an alkaloid compound with high purity and low cost. It has been verified that the alkaloid compound can be applied to anti-inflammatory drugs and anti-diabetic drugs.
Owner:XI AN JIAOTONG UNIV
A kind of timasteroid saponin compound and its preparation method and application
ActiveCN110627861BNovel structureSimple extraction and separation methodOrganic active ingredientsSteroidsHuman breastPharmaceutical Substances
The invention discloses a timasteroid saponin compound, a preparation method thereof and the application of the compound in the preparation of antitumor drugs. The compound is a spirostanol-type steroidal saponin with the molecular formula C 45 h 74 o 17 , the molecular weight is 886. The compound is extracted from the medicinal plant Zhimu by 75% ethanol, water-saturated n-butanol, and separated and purified by macroporous adsorption resin, silica gel column chromatography, ODS reversed-phase column chromatography, gel column chromatography and other methods. . The results of MTT experiments show that the compound has significant anti-tumor activity against human breast cancer cell line (MCF‑7) and human liver cancer cell line (HepG2), and is expected to become an anti-tumor drug candidate.
Owner:CHINA PHARM UNIV
Flavonoid compound of Bupleurum marginatum and preparation method thereof
ActiveCN108929352ASimple extraction and separation methodGood reproducibilitySugar derivativesSugar derivatives preparationChemical structureChemistry
The invention specifically relates to a novel flavonoid compound extracted and separated from Bupleurum marginatum and a preparation method thereof, belonging to the technical field of medicine. The compound has a chemical structure formula as shown in a formula I which is described in the specification. The preparation method for the flavonoid compound extracted and separated from Bupleurum marginatum comprises the following successive steps: extracting; concentration; extraction; silica gel column chromatographic separation; and Sephadex LH-20 chromatographic separation. The invention has the advantage that the extraction and separation method for the novel flavonoid compound extracted from Bupleurum marginatum is simple and has good reproducibility.
Owner:JIANGXI POZIN PHARMA
New application of cardiac glycoside compound
ActiveCN103191143BGood antitumor activitySimple extraction and separation methodOrganic active ingredientsSteroidsChemical compoundPharmaceutical drug
The invention discloses an application of a cardiac glycoside compound 12 beta-hydroxycalotropin in preparing medicines for treating and preventing tumors. The cardiac glycoside compound 12 beta-hydroxycalotropin has obvious antitumor activity and can be served as a lead compound for treating the tumors. Moreover, an extraction and separation method of the cardiac glycoside compound 12 beta-hydroxycalotropin provided by the invention is simple and practicable and low in cost, and has high efficiency and yield and good extract quality.
Owner:TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
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