Total toadpoison lactones extraction with anti-tumor function, preparation and application thereof

A technology of total bufolide and anti-tumor effect, applied in anti-tumor drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as low content of active ingredients, unstable clinical curative effect, and serious adverse reactions , to achieve the effects of low toxic and side effects, inducing tumor cell differentiation, and strong pharmacological effects
CN101209264AActive Publication Date: 2008-07-02吴宗好
0 Cites 31 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
吴宗好
Publication Date
2008-07-02

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention discloses a total bufogenin extract with antitumor function and also discloses a preparation method of the extract and application thereof in the preparation of antitumor medicines. The total bufogenin extract of the invention is prepared by organic solvent extraction, column chromatography separation and purification of dried toadskin; the content of total bufogenin is over 80 percent, wherein the content of resibufogenin is over 12 percent, the content of cinobufagin is over 4 percent, and the content of bufotalin is over 10 percent. Compared with the prior art, the invention eliminates bufotenine alkaloid which has irritation, is easy to cause hypersensitivity but has no antitumor activity, efficiently collects the effective part of total bufogenin which has significant antitumor activity, therefore pharmacological action is stronger, the clinical curative effect is higher and the toxic and side effect is lower. The total bufogenin extract can be prepared into various pharmaceutical preparations for clinical application, therefore the invention has the functions of killing tumor cells, inducing differentiation and apoptosis of tumor cells, inhibiting the neovascularization of tumor cells and lowering the neoplasm metastasis rate, etc.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to an active ingredient extract with anti-tumor effect, in particular to an extract of total bufolides (bufaxins, bufotoxins) with anti-tumor effect from dry toad skin and the extract The preparation method of the compound, the present invention also relates to the application of the total bufolide extract in the preparation of antitumor drugs, which belongs to the field of traditional Chinese medicine. Background technique

[0002] Cancer is a major killer that endangers human life. Research and development of effective anticancer drugs is a common task faced by drug researchers in the world. In the field of research and development of new anticancer drugs, it is the research and development of anticancer drugs that can transform tumor cells into normal cells (induce tumor cell differentiation), induce tumor cell apoptosis, inhibit tumor cell angiogenesis, and reduce tumor metastasis. At the same time, it is also the mos...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More