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3,4-ring-opening polyacylation grayananes diterpene compound and preparation method thereof

A technology for polyacylating Trichosanthes and compounds, which is applied in the field of phytochemistry, can solve problems such as no patents or literature reports, and achieve the effects of simple and easy separation method, novel structure and high efficiency

Inactive Publication Date: 2010-02-17
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] So far, a novel 3,4-ring-opened polyacylated xianveratane diterpene compound involved in the present invention has not been found to be patented or reported in the literature.

Method used

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  • 3,4-ring-opening polyacylation grayananes diterpene compound and preparation method thereof
  • 3,4-ring-opening polyacylation grayananes diterpene compound and preparation method thereof
  • 3,4-ring-opening polyacylation grayananes diterpene compound and preparation method thereof

Examples

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Embodiment

[0024] After pulverizing 11 kg of dried leaves of Pieris formosa D.Don, immerse in 25L of acetone aqueous solution with a volume concentration of 75%, make it completely submerged in acetone aqueous solution, and soak for 48 hours at room temperature to obtain an extract. Repeat the extraction twice and combine to obtain 50L extract;

[0025] Use the vacuum concentration method of the prior art to distill under reduced pressure until there is no acetone smell; press the volume ratio of extract: sherwood oil=1: 1, first use sherwood oil to extract the extract three times at room temperature, and each time sherwood ether consumption is 10L , after reclaiming sherwood oil, obtain extract; According to the volume ratio of extract: ethyl acetate=1:1, then use ethyl acetate to extract three times at room temperature, each ethyl acetate consumption 10L, concentrate under reduced pressure After that, 550g of ethyl acetate extract was obtained;

[0026] Put the ethyl acetate extract o...

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Abstract

The invention provides a novel 3,4-ring-opening polyacylation grayananes diterpene compound and also relates to a method for extracting and separating the 3,4-ring-opening polyacylation grayananes diterpene compound from Pieris Formosa. The obtained compound is determined as 3,4-seco-3,10-olide-5beta-hydroxy-6beta,7alpha, 11alpha,15alpha,16alpha-pentaacetoxy-14beta-propionyloxygrayan-4(19)-ene through structural identification and is called as pieris formosin E(1), and 3,4-ring-opening polyacylation grayananes diterpene which is discovered for the first time has the structural formula.

Description

technical field [0001] The invention relates to a novel compound, namely a 3,4-ring-opened polyacylated xveratran diterpene compound and a preparation method thereof, belonging to the field of phytochemistry. Background technique [0002] Pieris formosa D.Don is a plant of the genus Pieris in the Rhododendron family (Ericaceae). It is also known as Xingshan formosa D.Don, etc. It is mainly distributed in Hubei, Hunan, Jiangxi, Fujian, Sichuan, and Yunnan. , Tibet and other places. The plant is poisonous, and ingestion of the stems and leaves by livestock can cause coma. Mice were injected intraperitoneally with 1000mg / kg of chloroform extract of leaf water decoction, and symptoms such as head stretching, dyspnea, limb abduction, and ataxia appeared. Its fresh leaf juice can kill insects, and can also be used as a lotion to treat human ringworm, scabies and malignant sores. Since the plants of the genus Pieris, Rhododendron, Leucothoe, and Craibiodendron of the Rhododendro...

Claims

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Application Information

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IPC IPC(8): C07D307/93
Inventor 李蓉涛潘玉银李海舟李洪梅汪伟光宋鹤娇
Owner KUNMING UNIV OF SCI & TECH
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