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Novel compounds derived from myristic acid and anticancer compositions comprising the same

PendingCN122094928Acytotoxicstrong cytotoxicityOrganic chemistry methodsKetone active ingredientsCancer cellNutmeg extract
This invention relates to a novel compound derived from nutmeg and an anticancer composition comprising the same. The present invention isolates several novel compounds derived from nutmeg extract and confirms that most of these novel compounds exhibit cytotoxic activity against various cancer cell lines. Five compounds (3, 4, 6, 9, and 11) were identified as having high cytotoxic activity against gastric and colorectal cancers. In particular, the compound represented by chemical formula 3 was confirmed to not only effectively induce apoptosis by regulating the cell cycle of cancer cells but also effectively inhibit tumor growth in xenograft mouse models, thus making it an effective anticancer composition.
Owner:KOREA INST OF SCI & TECH