Application of DNA tetrahedral nanostructure as carrier of medicine for treating inner ear diseases

A nanostructure and tetrahedral technology, applied in the field of biomedicine, can solve the problems of biological toxicity and high carrier cost, achieve the effect of reducing cost, low synthesis cost, maintaining structural integrity and stability
CN113134093AActive Publication Date: 2021-07-20HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2021-07-20

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Abstract

The invention provides application of a DNA tetrahedral nanostructure as a carrier of a medicine for treating inner ear diseases. The DNA tetrahedral nanostructure reaches inner ear functional cells through round window injection. According to the invention, a mouse round window administration technology successfully proves that the DNA tetrahedral nanostructure can enter inner ear functional cells. Therefore, the enrichment of the DNA tetrahedral nanostructure in the hearing hair cell part of the inner ear is realized for the first time, and a new way is provided for conveying medicines for treating inner ear diseases. Meanwhile, nucleic acid molecules are natural and have the advantages of low toxicity, excellent biocompatibility and the like, and the synthesis price of framework nucleic acid is low (the injection cost of each time is about several yuan), so that the DNA tetrahedral nanostructure provided by the invention is an ideal drug carrier for treating inner ear diseases.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to the application of a DNA tetrahedral nanostructure as a carrier of drugs for treating inner ear diseases. Background technique

[0002] According to WHO statistics, more than 5% of the world's population suffers from hearing loss, most of which involve damage to inner ear tissues such as auditory neurons or cochlear sensory cells. Therefore, the research on inner ear diseases is the key research field of otological diseases.

[0003] In the current research, the treatment of inner ear diseases mostly adopts the way of surgical administration. The use of drug delivery vehicles to deliver targeted drugs to the inner ear through the vasculature has become a common method for the treatment of inner ear diseases. Among them, the development of synthetic drug delivery carriers provides a new way for the treatment of inner ear tissue damage diseases. For example, nanoparticles mo...

Claims

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