Toll-like receptor 9 (TLR9) blocking agent and application thereof

A blocker and receptor technology, applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problems of ambiguity, no effect, difference in effect intensity, etc., and achieve wide application Foreground, clear target, high blocking activity effect
CN101712957BInactive Publication Date: 2011-11-23THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Publication Date
2011-11-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a specific blocking agent of a Toll-like receptor 9 (TLR9). The blocking agent is a nonmethylated CpG nucleotide sequence segment, the core structure of which is a CGCG nucleotide sequence, and the length of the nonmethylated CpG nucleotide sequence segment is 12-30 nucleotides. The blocking agent can be specifically combined with the TLR9, can block the combination between other irritant aglucons and the TLR9 and inhibit the proinflammatory effect mediated by the receptor, and can be used for the adjuvant treatment of inflammatory resistance and allergy resistance and the preparation of an experiment reagent of immune inflammation.
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Description

technical field

[0001] The invention relates to an blocking agent, in particular to a Toll-like receptor 9 (TLR9) blocking agent and its application. Background technique

[0002] Pathogenic microorganisms infect the human body usually cause systemic or local immune inflammatory response. In the past, it was generally believed that microbial proteins and lipopolysaccharides were the main sources of immune stimulation, but recent studies have found that the unique unmethylated CpG nucleotide sequence fragments (CpG-ODN) in microorganisms also have immunostimulatory effects, suggesting anti-inflammatory, Anti-allergic strategies are not limited to traditional methods, but need to consider the inflammatory effect caused by clearing unmethylated CpG-ODN.

[0003] The inflammatory mechanism of unmethylated CpG-ODN is related to the TLR9 receptor (Toll like receptor 9) on many immune cells in mammals. TLR 9 receptor is a type I transmembrane protein, which can specifically recog...

Claims

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