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Traditional Chinese medicine contg. herbalycopic active component for anti-tumor and anti-oxidation, its prepn. method and use

An anti-tumor effect and anti-oxidation technology, applied in anti-tumor drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the research and application of anti-oxidation and anti-tumor effects of Eupatorium and its effective parts that have not been seen And other issues

Inactive Publication Date: 2007-02-14
肖培根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been no reports on the research and application of Eupatorium and its effective parts on anti-oxidation and anti-tumor effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation method of each effective part of LLE-A:

[0023] Take the whole grass (100kg) of Lycopus lucidus Turcz.var.hirtus Regel., and use 70% and 50% ethanol to reflux extract twice, the first extraction is 2 hours, and the second extraction is 1.5 hours , the amount of solvent added is 100kg / time, filter, combine the filtrates, reclaim the ethanol, and obtain the extract (its density is 1.32g / mL80°C); the extract is spray-dried (the inlet temperature is 22°C, and the outlet temperature is 90°C), 6.8kg of dry powder (LLE) was obtained. Take 100g of dry powder, dissolve it in 1mL of water, extract it with petroleum ether (1L / time*5 times), ethyl acetate (1L / time*10 times), and n-butanol (1L / time*10 times) to obtain petroleum Ether site (LLE-A.P), ethyl acetate site (LLE-A.E), n-butanol site (LLE-A.B) and water site (LLE-A.W).

Embodiment 2

[0025] The preparation method of each effective part of LLE-B:

[0026] Take 100g of dry powder (LLE), dissolve it in 1mL of water, and then use n-hexane (1L / time*5 times), dichloromethane (1L / time*5 times), ethyl acetate (1L / time*10 times), Extract with n-butanol (1L / time*10 times) to obtain n-hexane parts (LLE-B.H), dichloromethane parts (LLE-B.D), ethyl acetate parts (LLE-B.E), n-butanol parts (LLE -B.B) and water parts (LLE-B.W).

Embodiment 3

[0028] The preparation method of each effective part of MCCM:

[0029] Take 100g of dry powder (LLE), dissolve it with 70% ethanol, recover the ethanol from the soluble part, disperse it with water, and extract it with ethyl acetate and n-butanol successively to obtain the ethyl acetate part (MCCM2921), the n-butanol part (MCCM2922 ) and water part (MCCM2923); ethanol insoluble part is (MCCM2924).

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PUM

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Abstract

An antineoplastic and antioxidizing active component of bugleweed for preparing the antioxidizing and antineoplastic medicines is composed of more components respectively extracted by alcohol, petroether, ethyl acetate, n-butanol, n-hexane, dichloromethane, or their mixture. Its preparing process is also disclosed.

Description

Technical field: [0001] The present invention relates to the effective parts of Eupatorium extract containing anti-oxidation and anti-tumor effects and its preparation method; the present invention further relates to the pharmaceutical composition of said effective parts; the present invention also relates to said effective parts in the preparation of antioxidant and anti-tumor application in medicine. Background technique: [0002] Zeilan is a traditional Chinese medicine recorded in the 2005 edition of the Pharmacopoeia of the People's Republic of China, and it is the dry aerial part of Lycopus lucidus Turcz.var.hirtus Regel. It is bitter in taste, pungent in nature, slightly warm, and returns to the liver and spleen meridian. It has the functions of promoting blood circulation and removing blood stasis, promoting water circulation and reducing swelling. [0003] With the improvement of human living standards, cardiovascular disease has become one of the most serious dise...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/00A61P35/00
Inventor 肖培根聂波刘勇梁鑫淼徐青
Owner 肖培根
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