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Magnetic hydrogel as well as preparation method and application thereof

A magnetic water and hydrogel technology, applied in the field of medical materials, can solve the problems of poor mechanical properties, poor mechanical properties, and high biological toxicity of GelMA, and achieve the effects of reducing agglomeration, improving mechanical properties, and enhancing stability

Active Publication Date: 2022-04-29
广东省科学院生物与医学工程研究所
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the mechanical properties of GelMA are poor and still need to be strengthened.
[0005] It can be seen that although cobalt ferrite has high saturation magnetization, high magnetic permeability and large positive magnetocrystalline anisotropy constant, it is biologically toxic. Although GelMA is an ideal biomaterial, its mechanical properties are poor

Method used

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  • Magnetic hydrogel as well as preparation method and application thereof
  • Magnetic hydrogel as well as preparation method and application thereof
  • Magnetic hydrogel as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0060] This embodiment prepares a kind of magnetic hydrogel, and the specific process is:

[0061] Formic acid acrylate-modified iron cobalt acid MeCFO was added to PBS buffer solution at a concentration of 0.1% (w / v) and sonicated for 30 min to make it uniformly dispersed, and a solution A (0.1% MeCFO) was prepared. A certain amount of purchased EFL-GelMA-90 was weighed and dissolved in PBS buffer solution at a concentration of 10% (w / v), and placed in a water bath at 50° C. to dissolve to prepare solution B (10% GElMA). Irgacure 2959 was completely dissolved in PBS buffer solution at a concentration of 0.4% (w / v) to prepare solution C (0.4% Irgacure 2959). Take different amounts of A, B and C solutions and mix them with PBS buffer solution (see Table 1 for the dosage). After fully oscillating and mixing, put them into the mold, and carry out ultraviolet crosslinking for 10 minutes to solidify and form, and obtain magnetic materials with different MeCFO solid contents. Hydro...

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to magnetic hydrogel as well as a preparation method and application thereof. The magnetic hydrogel comprises a gel network structure which is obtained by crosslinking and curing double-bond silane coupling agent modified cobalt ferrite and a double-bond monomer modified biological macromolecular material. Cobalt ferrite is modified by using a double-bond-containing silane coupling agent, so that the biocompatibility of cobalt ferrite can be effectively improved, the agglomeration of cobalt ferrite is reduced, the stability of cobalt ferrite in a system and the bonding strength between cobalt ferrite and a biological macromolecular material are enhanced, and the mechanical strength of the biological macromolecular material can be improved; meanwhile, good magnetic thermal response and heating efficiency are kept, tumor tissue is killed, and cobalt ions obtained through biodegradation have cytotoxicity and can kill tumor part cells.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a magnetic hydrogel and its preparation method and application. Background technique [0002] Bone tumors are currently a public health challenge faced by the world. The incidence of primary bone tumors ranks among the top among common malignant tumors in children and adolescents, and their prognosis is poor. Moreover, most patients with advanced cancer will develop metastatic bone tumors. With the prolongation of the survival time of cancer patients, the incidence of bone metastasis has increased year by year, which has seriously threatened human health. Therefore, the exploration of bone tumor treatment has always been a hot spot in medical research. . The current traditional treatment methods mainly include surgery, chemotherapy, radiotherapy and so on. However, surgical treatment cannot completely remove the lesion of bone tumor. And because most bone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/02A61L27/50A61L27/52A61L27/54A61K41/00A61P35/00
CPCA61L27/222A61L27/025A61L27/54A61L27/52A61L27/50A61K41/0052A61P35/00A61L2300/10A61L2300/416A61L2430/02
Inventor 吴婷婷施奕万王兆振林承雄许为康
Owner 广东省科学院生物与医学工程研究所
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