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Photo-stimulated active oxygen responsive hollow mesoporous silica drug-loaded particle and preparation method and application thereof

A technology of mesoporous silica and silica, which can be used in pharmaceutical formulations, organic active ingredients, medical preparations of non-active ingredients, etc., can solve problems such as poor biocompatibility, low solubility, and lack of photostability. Achieve the effect of preventing leakage and enhancing suppression

Active Publication Date: 2021-07-13
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these fluorescent agents are far away from in vivo applications due to their poor biocompatibility, low solubility, and lack of photostability.

Method used

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  • Photo-stimulated active oxygen responsive hollow mesoporous silica drug-loaded particle and preparation method and application thereof
  • Photo-stimulated active oxygen responsive hollow mesoporous silica drug-loaded particle and preparation method and application thereof
  • Photo-stimulated active oxygen responsive hollow mesoporous silica drug-loaded particle and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Such as figure 1 As shown, the preparation method of hollow mesoporous silica drug-loaded particles responsive to light-stimulated active oxygen in this embodiment includes the following steps:

[0056] (1) Synthesis of reactive oxygen species ROS-cleavable thioketal linker (TK-OH)

[0057] Mix anhydrous mercaptoacetic acid and anhydrous acetone together, and use dry saturated hydrogen chloride, heat at room temperature for 6 hours after stirring, pour the mixture into an ice-water bath; wash the precipitated crystals with hexane and cold water; in a vacuum desiccator After drying, a white carboxy-terminal TK linker was obtained. The correctness of the molecular structure was determined by liquid-phase NMR.

[0058] LiAlH 4 Further reduction of the carboxy-terminal TK linker yields a hydroxyl-terminal TK linker. In short, the LiAlH 4 Added dropwise to an anhydrous solution of the carboxy-terminal TK linker in THF, refluxed for one hour; then this mixture was slowly...

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Abstract

The invention belongs to the technical field of functional medical materials, and particularly relates to a photo-stimulated active oxygen responsive hollow mesoporous silica drug-loaded particle and a preparation method and application thereof. The photo-stimulated active oxygen responsive hollow mesoporous silica drug-loaded particle comprises a hollow mesoporous silica carrier and a covalent binding prodrug loaded on the surface of the hollow mesoporous silica carrier, and drugs are loaded in a hollow inner cavity and mesopores of the hollow mesoporous silica carrier. According to the invention, covalent binding prodrugs are introduced on the surface of hollow mesoporous silica, so that loading of various drugs is realized; the covalent binding prodrug not only can prevent the drug from leaking in systemic circulation, but also can be used as a goalkeeper of the hollow mesoporous silicon dioxide carrier to control the release of the drug in the hollow mesoporous and enhance the inhibition on tumor growth.

Description

technical field [0001] The invention belongs to the technical field of functional medical materials, and in particular relates to a hollow mesoporous silicon dioxide drug-loaded particle responsive to light-stimulated active oxygen, a preparation method and an application thereof. Background technique [0002] At present, cancer can be treated by chemotherapy, radiation therapy and surgical resection, but it still cannot completely cure cancer, and cancer is still a global health problem. In the clinic, chemotherapy remains one of the most commonly used methods of treating cancer. However, some may cause serious side effects, one reason is that most chemotherapy drugs require the use of toxic excipients to improve their poor water-soluble intravenous administration, and another reason is that these formulations may lack tumor-targeting properties and cannot distinguish between tumor tissue and healthy tissue. New technologies have been used to try to reduce these side effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/55A61K47/54A61K31/12A61K31/4745A61K41/00A61K47/52A61P35/00
CPCA61K47/6949A61K47/52A61K47/546A61K47/55A61K41/0042A61K41/0071A61K31/12A61K31/4745A61P35/00A61K2300/00
Inventor 童再再王亚平张续江奕坤江国华
Owner ZHEJIANG SCI-TECH UNIV
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