Bacillus sp.N11-8 and active component thereof having antitumor action

A marine bacillus, anti-tumor activity technology, applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, bacteria, etc., can solve the problems of difficult drug sources, difficult large-scale preparation, and low content
CN103667097AActive Publication Date: 2014-03-26YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
Publication Date
2014-03-26

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Abstract

The invention relates to a Bacillus sp.N11-8 and an active component thereof having antitumor action, belonging to the technical field of marine microorganism medicine. The Bacillus sp.N11-8 is obtained by isolated culture in Antarctic Ocean water, and was collected at China Center for Type Culture Collection (Wuhan) on November 19, 2012; and the collection number is CCTCC NO:M2012459. The strain can stably express the active component having antitumor action. The active component has favorable acid / alkali stability and heat stability, and has bigger cytotoxic effect on multiple tumor cells and smaller cytotoxic effect on normal cells of humans. Thus, the Bacillus sp.N11-8 and the active component thereof have favorable research and application values.
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Description

technical field

[0001] The invention belongs to the technical field of marine microbial medicine, and in particular relates to a marine bacillus and its active component with antitumor effect. Background technique

[0002] Malignant tumor is a major disease that seriously endangers human health and is one of the main causes of population death in my country. In 2005, about 7.5 million people died of malignant tumors in the world, and about 1.3 million people died of cancer in my country every year, and the incidence rate is increasing year by year. Upward trend. Drug therapy is an important part of comprehensive therapy for malignant tumors. Classical cytotoxic antineoplastic drugs are the main means of chemotherapy at present, and will still occupy a dominant position for a long time in the future. Therefore, looking for anti-tumor active ingredients with new structure types or new mechanisms of action from natural organisms is a new trend in current anti-tumor drug researc...

Claims

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