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Chloric biphenyl cyclooctene lignan compounds and preparation thereof

A biphenylcyclooctene and compound technology, applied in the field of phytochemistry, can solve problems such as no patents or literature reports, and achieve the effects of novel structure and simple extraction and separation method

Inactive Publication Date: 2009-08-12
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] So far, a chlorine-containing biphenyl cyclooctene lignan compound involved in the present invention has not been found to have patents or literature reports

Method used

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  • Chloric biphenyl cyclooctene lignan compounds and preparation thereof
  • Chloric biphenyl cyclooctene lignan compounds and preparation thereof
  • Chloric biphenyl cyclooctene lignan compounds and preparation thereof

Examples

Experimental program
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Effect test

Embodiment

[0021] After 8 kg of dried Schisandra sphenanthera (Schisandra sphenanthera) fruit was pulverized, 25 L of acetone aqueous solution was mixed with 8 kg of pulverized Schisandra sphenanthera at a mass / volume ratio of Schisandra : mass concentration of 70% acetone aqueous solution=1:3, and mixed at room temperature Soak for 24 hours to obtain the extract, repeat the extraction three times and combine to obtain 75L of extract;

[0022] Concentrate under reduced pressure of the prior art to get 7.5L extract after concentrating to no acetone smell, press extract: ethyl acetate=1: 1 volume ratio, extract 3 with commercially available technical grade ethyl acetate Time, each ethyl acetate consumption is 7.5L, gets ethyl acetate extract 145.9g after recovery;

[0023] After mixing the ethyl acetate extract with 300g of silica gel with a particle size of 80-100 mesh, put it on a silica gel column for chromatographic separation. The silica gel column is glass fiber reinforced plastic si...

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Abstract

The invention relates to a novel compound, in particular to a chlorine-containing biphenyl cyclooctene-class lignan compound. The invention also relates to a method for extracting the chlorine-containing biphenyl cyclooctene-class lignan compound from Schisandra sphenanthera fruit. According to structural identification, an isolated substance obtained from the extraction has biphenyl cyclooctene-class lignan which is substituted by chloromethyl on an octatomic ring. Such phenomenon is discovered in advanced plants for the first time. The molecular formula of the isolated substance is C28H33O9Cl and is named chloromethyl schisantherin B which has the above structural formula.

Description

technical field [0001] The invention relates to a novel compound, especially a chlorine-containing biphenyl cyclooctene lignan compound and a preparation method thereof, belonging to the field of phytochemistry. Background technique [0002] Schisandra sphenanthera (Schisandra sphenanthera Rehd.et Wils) is a plant of the genus Schisandra in the family Schisandraceae, commonly known as "Southern Schisandra", and is mainly distributed in Sichuan, Hubei, Shaanxi, Shanxi, Yunnan, Henan and other places. The fruit effect of Schisandra chinensis is the same as Schisandra chinensis (S.chinensis). It is the raw material of Chinese medicine Nan Schisandra and Wuzhi Tablets. It has the effects of astringent, cough, sweat, diarrhea, nourishment and strength. Excessive venting, spontaneous sweating, night sweats, internal heat and thirst, palpitations and insomnia. Its stems and vines also have the effects of promoting menstruation and blood circulation, strengthening tendons and bones...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D317/70
Inventor 李蓉涛任荣李海舟李洪梅李晓蕾
Owner KUNMING UNIV OF SCI & TECH
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