Eucommia ulmoides extract and application thereof in treatment of osteoporosis

An extract and Eucommia bark technology, applied in the field of traditional Chinese medicine extraction, can solve the problems such as difficult control of active ingredient content, complex medicinal effect ingredient content, etc., and achieve the effects of simple and easy extraction and separation method, easy operation, and simple extraction method.

Inactive Publication Date: 2020-09-22
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The composition has a good effect on treating osteoporosis, but the content of the active ingredients in the mi

Method used

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  • Eucommia ulmoides extract and application thereof in treatment of osteoporosis
  • Eucommia ulmoides extract and application thereof in treatment of osteoporosis

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0041] Example 1-4 An extract of Eucommia ulmoides

[0042] Example Eucommia petroleum ether extract Eucommia Ethanol Extract Example 1 20 servings 10 servings Example 2 50 servings 30 servings Example 3 50 servings 10 servings Example 4 30 servings 30 servings

[0043] Preparation:

[0044] The preparation method of the eucommia petroleum ether extract is:

[0045] (1) First, clean the bark of Eucommia ulmoides, leaves of Eucommia ulmoides or the whole plant of Eucommia ulmoides, after drying, soak in 8 times the volume of 60% petroleum ether ultrasonically for 24 hours, filter, and collect filtrate A1 and filter residue a1;

[0046] (2) Add 5 times the volume of 60% petroleum ether to the filter residue a1 obtained in step (1) for reflux extraction at 80°C for 10 hours; filter, collect the filtrate A2, and discard the filter residue a2;

[0047] (3) Combine the filtrate A1 in step (1) and the filtrate A2 in step (2), and perform vacuum distillation to obtain the eucommia petrol...

Example Embodiment

[0052] Example 5-8 An extract of Eucommia ulmoides

[0053] Example Eucommia petroleum ether extract Eucommia Ethanol Extract Example 5 30 servings 10 servings Example 6 39 servings 13 servings Example 7 45 servings 15 servings Example 8 48 servings 16 servings

[0054] Preparation:

[0055] The preparation method of the eucommia petroleum ether extract is:

[0056] (1) First, clean the bark of Eucommia ulmoides, leaves of Eucommia ulmoides or the whole plant of Eucommia ulmoides, after drying, soak in 10 times the volume of 80% petroleum ether ultrasonically for 24 hours, filter, and collect filtrate A1 and filter residue a1;

[0057] (2) Add 6 times the volume of 80% petroleum ether to the filter residue a1 obtained in step (1) for reflux extraction at 75°C for 10 hours; filter, collect the filtrate A2, and discard the filter residue a2;

[0058] (3) Combine the filtrate A1 in step (1) and the filtrate A2 in step (2), and perform vacuum distillation to obtain the eucommia petro...

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Abstract

The invention provides eucommia ulmoides extract and an application thereof in treatment of osteoporosis, and belongs to the technical field of traditional Chinese medicine extraction. The eucommia ulmoides extract comprises the following components in parts by weight: 20-50 parts of eucommia ulmoides petroleum ether extract and 10-30 parts of eucommia ulmoides ethanol extract; the eucommia ulmoides extract can be effectively used for treating the osteoporosis by controlling the weight part ratio of the eucommia ulmoides petroleum ether extract to the eucommia ulmoides ethanol extract to be (1-5): 1. The invention further provides an extraction method of the eucommia ulmoides petroleum ether extract and the eucommia ulmoides ethanol extract. Due to the fact that different effective components are different in solubility in different solvents, the content of the effective components can be effectively adjusted by adopting different solvents for extraction; the used extraction separationmethod is simple and easy to implement; and the osteoporosis treating effect is good.

Description

technical field [0001] The invention belongs to the technical field of extracting traditional Chinese medicines, and in particular relates to an extract of Eucommia ulmoides and its application in treating osteoporosis. Background technique [0002] Osteoporosis is a systemic and systemic skeletal disease characterized by decreased bone mass and microstructural destruction of bone tissue, leading to increased bone fragility and increased fracture risk. Its clinical symptoms are mostly bone pain and fractures. For chronic diseases caused by multiple factors, the treatment cycle is relatively long. Although currently clinically used drugs for the treatment of osteoporosis, such as calcitonin, bisphosphonates, parathyroid hormone, estrogen, selective estrogen receptor modulators, etc., have achieved good curative effect, However, long-term medication will have negative effects. It has been found that the existing drugs can only thicken the thinned bone trabeculae, but cannot r...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61P19/10A23L33/105A61K129/00A61K127/00
CPCA23V2002/00A61K36/46A61K2236/333A61K2236/35A61K2236/39A23L33/105A61P19/10A23V2200/306A23V2200/30A23V2250/21
Inventor 陈梁李小锋夏淑英胡吉忠毛金娣张金良周朝忠
Owner JIANGXI POZIN PHARMA
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