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Application of nifedipine to preparation of medicine for preventing brain blood vessel injury caused by zero gravity

A nifedipine and cerebrovascular technology, which is applied in drug combinations, cardiovascular system diseases, medical preparations containing active ingredients, etc., can solve the problems that the weightlessness environment cannot be eliminated and the effect is limited, and the mechanism of action and toxic and side effects are clear , reduce time and cost, use safe effect

Inactive Publication Date: 2016-05-18
FOURTH MILITARY MEDICAL UNIVERSITY
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AI Technical Summary

Problems solved by technology

Theoretically, avoiding the weightless environment is the fundamental way to solve such problems, but the weightless environment cannot be eliminated, and some current protective measures and methods have limited effects. Therefore, the current simple and effective way is to find drugs to fight against

Method used

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  • Application of nifedipine to preparation of medicine for preventing brain blood vessel injury caused by zero gravity
  • Application of nifedipine to preparation of medicine for preventing brain blood vessel injury caused by zero gravity
  • Application of nifedipine to preparation of medicine for preventing brain blood vessel injury caused by zero gravity

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Embodiment Construction

[0023] The inventor’s previous research results (1.XieMJ, ZhangLF, MaJ, etal.Functional alteration sincerebrovascularK + andCa 2+ channelsarecomparablebetweensimulatedmicrogravityratandSHR[J].AmericanJournalofPhysiologyHeartandCirculatoryPhysiology,2005,289(3):H1265-H76.2.XieMJ,MaYG,GaoF,etal.ActivationofBK Ca channelisassociatedwithincreasedapoptosisofcerebrovascularsmoothmusclecellsinsimulatedmicrogravityrats[J].American Journal of PhysiologyCellPhysiology,2010,298(6):C1489-C500.3.ZhangLF.Region-specificvascularremodelinganditspreventionbyartificialgravityinweightlessenvironmentofcerebrovascularsmoothmusclecellsinsimulatedmicrogravityrats[J].Europeanjournal of 287 Changes in the distribution of systemic arterial blood flow can lead to specific regional remodeling of blood vessels in different parts of it, that is, cerebral artery hypertrophy and increased contraction function, and mesenteric arterioles atrophic changes, etc., and studies have shown that L-type Ca 2+ The channel...

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Abstract

The invention discloses application of nifedipine to preparation of medicine for preventing brain blood vessel injury caused by zero gravity. The nifedipine can realize differential regulation and control on the function of brain and mesenteric small artery of simulated zero gravity rats through the inhibition effects on L type Ca<2+> channels, i.e., the nifedipine can recover the function of the brain artery blood vessels of the simulated zero gravity rats through inhibiting the L type Ca<2+> channels of smooth muscle cells of the brain artery blood vessels; and the nifedipine does not have the obvious influence on the function of the mesenteric small artery blood vessels and the L type Ca<2+> channels of smooth muscle cells of the simulated zero gravity rats.

Description

Technical field [0001] The invention belongs to the technical field of preventing and treating cerebrovascular remodeling caused by weightlessness and other environments, and relates to the application of nifedipine in preventing and treating cerebrovascular damage. Background technique [0002] Aerospace activities are a special activity. When conducting aerospace activities, the human body is in a weightless / microgravity environment. In this case, the blood in the human body that has adapted to the 1G gravity of the earth's surface will shift headward and thus bring about A series of physiological and psychological problems have an impact on the physical health and work efficiency of astronauts. When the space flight activities are over and the astronauts return to the 1G gravity environment on the earth's surface, their cardiovascular functions will have obvious dysfunction. Phenomenon, such as poor orthostatic endurance and decreased exercise endurance. The incidence an...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61P9/00A61P9/12
Inventor 谢满江张海军白云刚
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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