Method for amplifying and activating LAK cells by non-fetus bovine serum
A technology of fetal bovine serum and NK cells, applied in the field of immunology, can solve problems such as difficulty in obtaining high purity, low purity of LAK cells, and inability to meet clinical needs, and achieve the effect of improving killing ability and resisting viruses and bacteria
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[0040] The invention discloses a method for amplifying and activating lymphocytes without fetal bovine serum, using host cells transfected with protein A, protein B, protein C, protein D, protein E, and protein F, combined with various proteins to stimulate lymphocytes Perform expansion and activation to obtain LAK lymphocytes; the host cells after transfection play an important role in the expansion and activation of lymphocytes, and sufficient number and function of LAK cells can be obtained, which can recognize and destroy tumor microenvironment Tumor cells, M2-type monocytes and CD19+ B cells enhance the patient's immune response. The protein A contains the functional fragments of CD8α and interleukin 21; the protein B contains the functional fragments of CD14; the protein C contains the functional fragments of CD19; the protein D contains the functional fragments of CD86; the protein E contains the functional fragments of CD163; Contains the functional fragment of CD137L;...
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