Small two-stage vacuum rectangular ion trap mass spectrometer and detection method thereof

Abstract

The invention provides a small two-stage vacuum rectangular ion trap mass spectrometer and a detection method thereof. The mass spectrometer comprises two stages of vacuum cavities. The first-stage vacuum cavity is internally provided with an atmospheric pressure interface sampling cone, a quadrupole rod and an ion gate electrode which form a quadrupole ion trap. The second-stage vacuum cavity is internally provided with a rectangular ion trap, an ion detector and a capillary tube. An ion optical element is arranged between the two stages of vacuum cavities. The detection method includes the steps that the quadrupole ion trap in the first-stage cavity is controlled to be in an ion trap storage mode and an ion trap synchronous analysis mode so that sensitivity of mass spectra can be improved, the quantitation limit is reduced, analysis flux is increased, influences of the space charge effect are reduced, and the resolution is increased. The quadrupole rod does not need high resolution and is low in processing precision requirement. Besides, the rectangular trap is easy to process and assemble, so that miniaturization is facilitated. Meanwhile, the detection method can guarantee good analysis performance and has wide application prospects in the field of on-site analysis and detection.

Description

technical field [0001] The invention relates to the field of in-situ and on-site detection of biochemical substances by using a mass spectrometer, in particular to a small rectangular ion trap mass spectrometer with a secondary vacuum system and a detection method for improving its analysis performance. Background technique [0002] Mass spectrometry is a universal chemical analysis method with high specificity, high sensitivity and wide application. In recent years, the increasing demand for in-situ analysis and on-site detection has led to the rapid development and application of miniaturized mass spectrometers. Among all kinds of mass spectrometers, ion trap mass spectrometers play a huge role in life sciences, medicine and health, environmental monitoring, food safety and other fields due to their relatively simple structure and powerful time-tandem mass spectrometry capabilities. However, the traditional linear ion trap is not convenient for miniaturization due to the ...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a small rectangular ion trap mass spectrometer with a two-stage vacuum system and a detection method for improving its analytical performance, so as to overcome the problem of simple structure but low performance of the small-scale mass spectrometer with a first-stage cavity, and at the same time overcome Although the existing commercial mass spectrometer has high performance, but the system is complicated, the mass spectrometer not only has a simple structure, does not require high processing accuracy, is convenient for miniaturization, but also has good analytical performance

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