A human brain local water distribution volume determination method with a front A% area as the reference area

A determination method and technology for water distribution, applied in the field of biological and medical imaging, can solve problems such as insufficient accuracy, achieve good application scenarios, and facilitate automatic processing.

Active Publication Date: 2016-06-22
哈尔滨本洪生物科技有限公司
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Problems solved by technology

[0008] In order to solve the deficiencies of the prior art, the object of the present invention is to provide a method for measuring the local water distribution volume of the human brain in which the front A% area is used as a reference area, so as to solve the lack of accuracy of the prior art in measuring the local water distribution volume of the human brain technical issues

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  • A human brain local water distribution volume determination method with a front A% area as the reference area
  • A human brain local water distribution volume determination method with a front A% area as the reference area
  • A human brain local water distribution volume determination method with a front A% area as the reference area

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Embodiment Construction

[0025] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0026] refer to figure 1 As shown, the method for measuring the local water distribution volume of the human brain in the front A% area of ​​the present invention as the reference area is a PET / H method for the local water distribution volume of the human brain. 2 15 O non-invasive quantitative measurement method, which can quantitatively measure the human brain pixel by pixel, and then generate functional images of the local water distribution volume of the human brain. In order to realize the above-mentioned purpose of the invention, the present invention is achieved by taking the following technical solutions:

[0027] The method for quantitatively measuring the volume of distribution of human brain local water as a reference area in the front A% area is characterized in that:

[0028] (1) PET / H for human brain 2 15 O dynamic scan...

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Abstract

The invention provides a human brain local water distribution volume determination method with a front A% area as the reference area. The method comprises the steps of firstly performing PET/H2150 dynamic scanning on a human brain; secondly calculating the relative water distribution volume value P1 of each to-be-determined part in the human brain with the front A% area of the human brain as the reference area; thirdly, performing normalization processing of the human brain after calculating the relative water distribution volume value P1 of each part in the human brain. An obtained value is different from the absolute water distribution volume of the part only by a proportional constant, and the value is used as the index of the absolution water distribution volume. The method requires no dynamic arterial blood drawing, possibly-fuzzy template or model, and manual intervention such as complex correction, thereby facilitating automatic processing of a computer; the determined result does not differ from that of an accurate local water distribution volume quantitative determination method, so that the method enjoys a bright application prospect.

Description

technical field [0001] The invention relates to a method for measuring the local water distribution volume of the human brain, in particular to a method for measuring the local water distribution volume of the human brain using the front A% area as a reference area. The invention belongs to the field of biological and medical imaging. Background technique [0002] Using Positron Radionuclides 15 O labeled water (i.e. H 2 15 O) Positron Emission Tomography (PET) method (abbreviated as PET / H) as imaging agent 2 15 O method) is to carry out PET dynamic scanning after intravenous injection of H215O, and then use the Kety-Schmidt single-compartment model (for literature, see KetySS. (1951) The theory and application of the exchange of finert gas atthelungs and tissues. PharmacolRev3: 1-41.) and other methods for pixel-by-pixel quantification of local water distribution volume Compute, which produces an image of the local water distribution volume. [0003] In the early quan...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03
CPCA61B6/037A61B6/469A61B6/481A61B6/501A61B6/52
Inventor 吴义根郑改革赵德林
Owner 哈尔滨本洪生物科技有限公司
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