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lncRNA ENST00000581794.1 and preparation, diagnostic agent, medicine or kit and application

A technology of kits and diagnostic agents, applied in the field of genetic engineering, can solve problems such as the unclear role of genetics

Inactive Publication Date: 2016-07-27
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a long-chain non-coding RNA ENST00000581794.1 preparation or diagnostic agent or drug or kit, which overcomes the deficiencies in the prior art and can effectively solve the problem of acute myocardial infarction as a condition affected by various genetic and environmental factors. However, the role of genetics in the pathogenesis of acute myocardial infarction is still unclear. The present invention finds that its abnormal expression or function is closely related to the occurrence and development of human cardiovascular diseases. Long non-coding RNA is expected to become a It is a marker for disease diagnosis and prediction of prognosis, and also provides a new target for the treatment of cardiovascular diseases

Method used

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  • lncRNA ENST00000581794.1 and preparation, diagnostic agent, medicine or kit and application
  • lncRNA ENST00000581794.1 and preparation, diagnostic agent, medicine or kit and application

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Example 1, a long non-coding RNA ENST00000581794.1 highly expressed in the blood of patients with acute myocardial infarction, the sequence of the long non-coding RNA ENST00000581794.1 is shown in SEQ ID NO:1.

Embodiment 2

[0026] Example 2, as an optimization of Example 1, the long non-coding lncRNA ENST00000581794.1 is the full length of ENST00000581794:1.

Embodiment 3

[0027] Embodiment 3, a preparation or diagnostic agent or medicine or kit for in vitro detection of long-chain non-coding RNAENST00000581794.1 in blood according to Embodiment 1 and Embodiment 2, the preparation or diagnostic agent or medicine or kit comprises A pair of specific primers, a standard DNA template, and a PCR reaction solution, wherein the pair of specific primers includes an upstream primer and a downstream primer, the nucleotide sequence of the upstream primer is SEQ ID No: 2, and the nucleotide sequence of the downstream primer is SEQ ID No: 3.

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Abstract

The invention relates to the technical field of genetic engineering, and discloses long-chain non-encoded RNA ENST00000581794.1 as well as a kit and an application thereof. The sequence of the long-chain non-encoded RNA ENST00000581794.1 is as shown in SEQ ID NO:1. A long-chain non-encoded expression profile chip technique is used, and a piece of lncRNA ENST00000581794.1 which is remarkably and highly expressed in blood of patients suffering from acute myocardial infarction can be screened through differential analysis, so that study on pathogenesis of acute myocardial infarction is further enriched.

Description

technical field [0001] The invention relates to the technical field of genetic engineering, and is a long-chain non-coding RNAENST00000581794.1 and its kit and application, that is, lncRNAENST00000581794.1 and its preparation or diagnostic agent or drug or kit and application. Background technique [0002] Acute myocardial infarction (acute myocardial infarction, AMI) is a serious type of coronary heart disease (Coronary heart disease, CHD). At present, the diagnosis of acute myocardial infarction mostly depends on clinical manifestations, dynamic changes of electrocardiogram and serum biomarkers. How to diagnose and prevent acute myocardial infarction earlier has always been an important topic of our research. With the completion of the Human Genome Project and the development of gene chip technology, many causative genes of single-gene diseases have been discovered and applied to the diagnosis and treatment of diseases. As AMI is a disease affected by multiple genetic an...

Claims

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Application Information

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IPC IPC(8): C12N15/113C12Q1/68
CPCC12N15/113C12N2310/10C12Q1/6883C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 翟慧杨毅宁李晓梅马依彤刘芬陈邦党谢翔吴红艳付准
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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