Glycoprotein hormone long-acting superagonists

A glycoprotein hormone, animal technology, applied in the field of glycoprotein hormones, can solve the problems of weakening response, increasing half-life bioavailability, etc.
CN105873602AInactive Publication Date: 2016-08-17TROPHOGEN INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TROPHOGEN INC
Publication Date
2016-08-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type counterparts. The analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity.
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Description

technical field

[0001] The present invention generally relates to modified glycoprotein hormones having superagonist activity and their use in the treatment of conditions associated with glycoprotein hormone activity. More specifically, the present invention relates to modified glycoprotein molecules that contain amino acid substitutions and one or more inserted peptides in the alpha subunit compared to the wild type alpha subunit, wherein such modified molecules are different from the wild type Glycoproteins exhibit enhanced pharmacological properties compared to glycoproteins. Background technique

[0002] The gonadotropins follicle-stimulating hormone (follicle-stimulating hormone, FSH) and chorionic gonadotropin (CG), luteinizing hormone (luteinizing hormone, LH), and thyrotropin (thyroid-stimulating hormone, TSH) constitute the glycoprotein hormone family . Each hormone is a heterodimer of two non-covalently linked subunits, an alpha subunit and a beta subunit. The a...

Claims

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