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Preparation method for wild chrysanthemum flower liver-protection soft capsule

A technology of soft capsule and wild chrysanthemum is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of low price, easy industrial production and beautiful appearance.

Inactive Publication Date: 2016-09-07
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No wild chrysanthemum soft capsule preparation with hepatoprotective and hepatoprotective effects has been found in commercially available products

Method used

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  • Preparation method for wild chrysanthemum flower liver-protection soft capsule
  • Preparation method for wild chrysanthemum flower liver-protection soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Prepare the raw materials of Wild Chrysanthemum Baogan Soft Capsules according to the following weight: Wild Chrysanthemum Extract: 5g, Flaxseed Oil: 100g, Span-80: 0.5g, Vitamin E: 0.5g;

[0023] (2) After mixing the wild chrysanthemum extract, linseed oil, Span-80, and vitamin E, encapsulate it with a soft capsule material made of gelatin, glycerin and pure water, place it in a soft capsule machine, and adjust the capsule machine The working parameters are as follows: the temperature of the plastic box is 40°C, the temperature of the spray body is 30°C, the rotation speed is 2r / min, the thickness of the rubber is 0.90mm, and the capsules are filled with medicine to obtain soft capsules;

[0024] (3) Place the soft capsules at 28°C and 20% relative humidity, and dry them in a tumbler for 36 hours.

Embodiment 2

[0026] (1) Prepare the raw materials of Wild Chrysanthemum Protecting Liver Soft Capsules according to the following weight: Wild Chrysanthemum Extract: 50g, Linseed Oil: 600g, Span-80: 5g, Vitamin E: 5g;

[0027] (2) After mixing the wild chrysanthemum extract, linseed oil, Span-80, and vitamin E, encapsulate it with a soft capsule material made of gelatin, glycerin and pure water, place it in a soft capsule machine, and adjust the capsule machine The working parameters are: the temperature of the plastic box is 60°C, the temperature of the spray body is 50°C, the rotation speed is 4r / min, the thickness of the rubber is 1.00mm, and the capsules are filled with medicine to obtain soft capsules;

[0028] (3) Place the soft capsules at 32°C and 30% relative humidity, and dry them in a tumbler for 60 hours.

Embodiment 3

[0030] (1) Prepare the raw materials of Wild Chrysanthemum Protecting Liver Soft Capsules according to the following weight: Wild Chrysanthemum Extract: 25g, Linseed Oil: 350g, Span-80: 2.8g, Vitamin E: 2.8g;

[0031] (2) After mixing the wild chrysanthemum extract, linseed oil, Span-80, and vitamin E, encapsulate it with a soft capsule material made of gelatin, glycerin and pure water, place it in a soft capsule machine, and adjust the capsule machine The working parameters are: the temperature of the plastic box is 50°C, the temperature of the spray body is 40°C, the rotation speed is 3r / min, the thickness of the rubber is 0.95mm, and the capsules are filled with medicine to obtain soft capsules;

[0032] (3) Place the soft capsules at 30° C. and 25% relative humidity, and dry them in a tumbler for 48 hours.

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Abstract

The invention belongs to the field of pharmaceutic preparations and in particular relates to a preparation method for a wild chrysanthemum flower liver-protection soft capsule. The wild chrysanthemum flower liver-protection soft capsule is prepared from the following raw materials in parts by weight: 5-50 parts of wild chrysanthemum flower extract, 100-600 parts of linseed oil, 0.5-5 parts of span 80, and 0.5-5 parts of vitamin E. The wild chrysanthemum flower liver-protection soft capsule is prepared by the following steps: mixing the wild chrysanthemum flower extract, the linseed oil, the span 80 and the vitamin E, packaging the mixture by using soft capsules, placing the packaged soft capsules in a soft capsule machine, and performing medicine charging and capsule manufacturing, thereby obtaining the soft capsules; placing the soft capsules at 28-32 DEG C under the relative humidity of 20-30%, and performing tumble dry for 36-60 hours. According to the preparation method for the wild chrysanthemum flower liver-protection soft capsule, provided by the invention, the content of effective ingredients in wild chrysanthemum flower soft capsules is improved; active part extracts with functions of resisting hepatitis B virus and protecting the liver are combined with the linseed oil with a wide healthcare function to generate a synergistic effect, so that natural healthy wild chrysanthemum flower liver-protection soft capsules are prepared.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of Yejuhua Baogan Soft Capsules. Background technique [0002] Human beings have been plagued by hepatitis B virus since ancient times. It is a hepatotropic virus that exists in liver cells and damages liver cells, causing inflammation, necrosis, and fibrosis of liver cells. It is currently the most contagious, highest incidence, and harmful One of the largest viral diseases. But so far there is still no effective means of control and a thorough solution to hepatitis B at home and abroad, and there is no specific medicine. No wild chrysanthemum soft capsule preparation with hepatoprotective and hepatoprotective effects has been found in commercially available products. Traditional Chinese medicine soft capsule preparations are widely used in clinics due to their beautiful appearance, uniform dispersion, stability, accurate loading, and...

Claims

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Application Information

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IPC IPC(8): A61K36/287A61K36/55A61K9/66A61K47/44A61P1/16A61P31/20
CPCA61K36/287A61K9/4858A61K36/55A61K2300/00
Inventor 毕跃峰徐霞高振孟小倩李淑敏杨小敏
Owner ZHENGZHOU UNIV
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