Compound composition and its medicinal use

A composition, a technology of a pharmaceutical composition, applied in the field of medicine, can solve problems such as inappropriate dosage and course of treatment, lack of neuroprotective drugs, poor pharmacokinetics and pharmacodynamics, etc.

Active Publication Date: 2019-05-24
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a lack of effective neuroprotective drugs clinically. Even neuroprotective drugs that are confirmed to be effective in the preclinical stage often fail in clinical trials.
There are many reasons for the failure of clinical trials of neuroprotective agents. At present, the main reasons are: severe adverse reactions; inappropriate study type, sample size and observation indicators; inappropriate treatment dose and course of treatment; poor pharmacokinetics and pharmacodynamics; Narrow treatment window, etc.

Method used

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  • Compound composition and its medicinal use
  • Compound composition and its medicinal use
  • Compound composition and its medicinal use

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Experimental program
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Embodiment Construction

[0020] Briefly introduce the relevant prior art situation first.

[0021] Traumatic brain injury is divided into primary injury and secondary injury. Primary injury is the neuron damage directly caused by strong external impact, most of which are irreversible damage, mainly manifested as intracranial hematoma and other diffuse damage. The pathophysiological mechanism of secondary injury is extremely complex, involving focal cerebral ischemia, excitotoxicity, oxidative damage, inflammatory response, Ca 2+ Multiple mechanisms such as overload and osmotic effects. Therefore, research on the pathophysiological mechanism and prevention and treatment of brain injury after TBI is one of the research hotspots in the field of neuroscience in recent years. Although scientists have made unremitting efforts for decades and laboratory research has achieved brilliant results, the results of clinical trials have been disappointing, and no drug has yet achieved satisfactory curative effects...

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Abstract

The invention discloses a compound composition and medical application thereof. The compound composition is prepared from serine and taurine. With the adoption of the manner, the compound composition has an effective medical effect on the aspects of traumatic injuries and neuroprotection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound composition and its medical use. Background technique [0002] Traumatic Brain Injury (Traumatic Brain Injury, TBI for short) is one of the common emergencies in the field of neurosurgery, especially severe TBI, with a mortality rate of 30%-50%; even if survived, 10% of patients with moderate or mild injuries will Remaining permanent disability, and the proportion of moderate and severe patients remaining permanent disability can reach 66% and 100%. TBI has become the first cause of death and disability among young adults under the age of 35 in the world. In my country, with the rapid development of economy, the transportation industry, construction industry, and sports industry have developed very rapidly, and accidental injuries such as traffic accidents, construction work injuries, and sports accidents have greatly increased, resulting in an increase in the incide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61P25/00A61P25/28A61K31/185
CPCA61K31/185A61K31/198A61K2300/00
Inventor 王国华姜正林张元媛李霞徐丽华
Owner NANTONG UNIVERSITY
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