Coptidis total alkaloids vaginal suppository

Abstract

The invention discloses a coptis chinensis total alkaloid vaginal suppository, which is prepared by mixing of the following raw materials by mass: 6%-24% of coptis chinensis alkaloid, and 76%-94% of matrix. And the pH is controlled at 3.8-5.0. Further, the coptis chinensis total alkaloid vaginal suppository is an adhesive suppository, and is prepared by mixing of the following raw materials by mass: 3%-12% of coptis chinensis total alkaloid, 1%-4% of osthole, 1%-4% of aloe polysaccharide, 1%-4% of Hedyotis diffusa total flavone, 1-16% of a bioadhesive agent, and 60%-93% of matrix. The coptis chinensis total alkaloid vaginal suppository is for local medication, the efficacy is concentrated at a part of vagina, thus avoiding the first pass effect and liver, kidney toxicity caused by oral medication, extending the retention time of drug in vagina, at the same time solving the increasingly serious drug resistance and high recurrence rate problems caused by chemical drugs in VVC (vulvovaginal candidiasis) and RVVC (recurrent vulvovaginal candidiasis) treatment, and achieving the purpose of improving the treatment effect.

Description

technical field [0001] The invention relates to a suppository, in particular to a total alkaloid vaginal suppository of coptis. Background technique [0002] Vulvovaginal candidiasis (VVC) is a common vulvovaginal inflammatory disease. In recent years, with the widespread use of clinical antibiotics, the increase of women using oral contraceptives, the increase in the incidence of diabetes and other factors, the incidence and recurrence of VVC have shown an obvious upward trend. According to foreign epidemiological statistics: 5% of VVC patients suffer from 4 or more episodes per year, which is called recurrent vulvovaginal candidiasis (RVVC). Therefore, the recurrence of VVC has become an urgent clinical problem to be solved. [0003] Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsial or Coptis teeta Wall. have a long history of clinical application in my country. The main ingredients are alkaloids. [0004] Coptidis total alkaloids gelatin microspheres can be...

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Problems solved by technology

[0004] Coptidis total alkaloids gelatin microspheres can be seen in the existing domestic literature [Jia Yongyan, Yuan Yuxia, Zhou Ning, etc. Optimization of the preparation process of Coptidis total alkaloids gelatin microspheres[J], Chinese Journal of Experimental Formulas, 2013, 19(11) :11-13.], pH-dependent total alkaloids of Coptis chinensis colon-targeted pellets [Ling Xiao, Hu Yuanli, Chen Feilong et al. Preparation of pH-dependent total alkaloids of Coptis chinensis colon-targeted pellets and their release properties in vivo and in vitro Evaluation[J]. Chinese Journal of Experimental Formulas, 2014,20(21):24-27.], Coptidis ointment [Guan Zhiyu, Chen Lihua, Wang Sen, etc. Optimization of the preparation process of Coptis ointment [J]. Chinese Journal of Experimental Formulas, 2012,18(17):36-38.] and other oral or transdermal preparations, no related vaginal preparations

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