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Novel application of echinacoside and acteoside

A technology of echinacoside and ergosteroside, which is used in medical preparations containing active ingredients, cardiovascular system diseases, urinary system diseases, etc., can solve the problem that there are no echinacoside and ergosteroside angiogenesis inhibitors Reports and other issues to achieve the effect of broad market prospects

Inactive Publication Date: 2016-12-21
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Echinacoside and ergoside have antioxidant and free radical scavenging effects, but there are no related reports about echinacoside and ergoside as angiogenesis inhibitors

Method used

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  • Novel application of echinacoside and acteoside
  • Novel application of echinacoside and acteoside
  • Novel application of echinacoside and acteoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Effects of echinacoside and ergosteroside on proliferation inhibition and apoptosis induction of vascular endothelial cells EA.hy926

[0022] 1 Materials and methods

[0023] 1.1 Drugs and reagents

[0024] RPMI 1640 medium (Gibco); fetal bovine serum (MDgenics); trypsin (Hyclone); DMSO (sigma); CCK-8 kit (Dojindo); Hoechst33342 staining solution, Annexin V-FITC cell apoptosis Death kit; echinacoside (batch number: PS0004-0020), ergosteroside (batch number: PS0001-0020).

[0025] 1.2 Instruments

[0026] Cell culture incubator (Nuaire Company); fluorescence microscope (Olympus Company); 5810R desktop centrifuge (Eppendorf Company); multifunctional microplate reader (Synergy HT Company); FACScalibur flow cytometer (Becton Dickinson Company).

[0027] 1.3 Cell culture

[0028] Human umbilical vein endothelial cells EA.hy926 (American Type Culture Collection ATCC). Cells were seeded in culture flasks containing complete medium at 37°C, 5% CO 2 Cultivate in ...

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Abstract

The invention provides application of echinacoside or acteoside in preparation of angiogenesis inhibitor medicines. Tests prove that angiogenesis echinacoside and acteoside can be used for effectively inhibiting reproduction of vascular endothelial cells, can be used as angiogenesis inhibitors for treating tumors, diabetic retinopathy, rheumatoid arthritis, prostatic hyperplasia or psoriasis and other angiogenesis dependent diseases and have a wide market prospect.

Description

technical field [0001] The present invention relates to the new application of echinacoside and ergosteroside. Background technique [0002] Angiogenesis refers to the formation of new microvessels in the form of budding, bridging, or intussusception through endothelial cell migration, proliferation, differentiation, and degradation of extracellular matrix on the basis of the original microvessels, and under the regulation of related signaling pathways. The regulation process of blood vessels can be divided into physiological angiogenesis and pathological angiogenesis. Physiological angiogenesis is an orderly regulatory process that only occurs in specific periods and locations such as embryonic development and tissue damage repair. Pathological angiogenesis is associated with a series of angiogenesis-dependent diseases such as tumors, diabetic retinopathy, rheumatoid arthritis, benign prostatic hyperplasia, and psoriasis. [0003] For example, tumor growth and metastasis ...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61K31/7028A61P35/00A61P9/10A61P27/02A61P19/02A61P13/08A61P17/06
CPCA61K31/7032A61K31/7028A61K2300/00
Inventor 王毓杰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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