43 results about "Angiogenic inhibitors" patented technology

The problems of the present invention are to find a pharmaceutical composition and a method for treating cancer that exhibit excellent anti-tumor effect. Excellent anti-tumor effect is achieved when 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, an analogous compound thereof, a pharmacologically acceptable salt thereof or a solvate thereof is used in combination with taxane.

The invention belongs to the technical field of organic synthetic medicines, and particularly relates to a substituted 1-(isoxazol-3-yl)-3-(3-fluoro-4-phenyl) urea derivative, and a preparation methodand use thereof. The substituted 1-(isoxazol-3-yl)-3-(3-fluoro-4-phenyl) urea derivative has a structural formula shown in Formula I. The invention also provides the preparation method of the substituted 1-(isoxazol-3-yl)-3-(3-fluoro-4-phenyl) urea derivative and use of the substituted 1-(isoxazol-3-yl)-3-(3-fluoro-4-phenyl) urea derivative in preparation of FMS-tyrosine kinase 3 inhibitors. A new and effective choice is provided for the preparation of the kinase inhibitors, the preparation of drugs for anti-autoimmune diseases, the preparation of neovascularization inhibitors and anti-tumordrugs in the field, and the substituted 1-(isoxazol-3-yl)-3-(3-fluoro-4-phenyl) urea derivative has a good application prospect.

The present invention relates to a pharmaceutical composition, a kit and a method for treating cancer and/or a method for inhibiting angiogenesis, comprising a sulfonamide compound in combination with Bevacizumab.

Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:

The invention relates to a temperature-controlled sustained-release injection containing an alkylating agent and a preparation method thereof, the temperature-controlled sustained-release injection comprises effective anti-cancer amount of the alkylating agent, an amphiphilic block copolymer, a solvent and a certain amount of drug release regulator, wherein, the mixture of the amphiphilic block copolymer and a solvent without organic solvent has the temperature-sensitive gelatinization feature, which is flowable liquid in the environment that is lower than the body temperature and can be automatically converted to the water-insoluble gel that can not flow and be biodegradable for absorption in an endotherm, and the water-insoluble gel can allow the contained angiogenesis inhibitor to have the local sustained release in a tumor and maintain the effective drug concentration for a plurality of weeks to a plurality of months. The sustained-release gel injection can be injected in the tumor or the tumor periphery or be arranged in the postoperative tumor cavity, thus significantly reducing the systemic reaction of the drug and being used for the treatment of the tumors in different stages. The alkylating agent is selected from cyclophosphamide, melphalan, leukeran, 4H-cyclophosphamide peroxide, norcantharidin, mannosulfan, treosulfan, ritrosulfan, ethoglucid, pipobroman, piposulfan, pumitepa, uredepa, azatepa and so on.

Methods and systems for isolating, assessing and treating lung compartments are disclosed. One or more lung compartments are accessed through an isolation catheter, oxygen rich gas is delivered to the compartments, and blood oxygen or exhaled carbon dioxide are monitored to assess lung compartment function. Diseased lung compartments may be treated using therapeutic agents delivered to the diseased compartments through the isolation catheter. Therapeutic agents include carbon monoxide, radioactive agents, chemotherapeutic agents or angiogenesis inhibitors and angiocidal agents.

The invention relates to a preparation method of an oyster shell extract. The method comprises the following steps of: adding water-containing solution of alcohol into oyster shell powder in a material to liquid ratio of 1g:2-20mL, performing reflux extraction and filtering or centrifugally separating liquid out; and concentrating the obtained liquid under reduced pressure, extracting with an organic solvent, separating an organic solvent layer out, concentrating under reduced pressure and drying to obtain the oyster shell extract. Tests by a lissamine rhodamine B method indicate that the prepared oyster shell extract has the function of inhibiting cell proliferation of a plurality of tumor cell strains; and tests by a methyl thiazolyl tetrazolium method indicate that the oyster shell extract has the function of inhibiting cell proliferation of human umbilical vein endothelial cells. Experiments indicate that the oyster shell extract can play a role in resisting tumors by inhibiting tumor cell proliferation and angiogenesis. Therefore, the oyster shell extract of the invention can be taken as a cell proliferation inhibitor, an angiogenesis inhibitor and an anti-tumor agent.

Compounds having the formula

are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

The invention relates to a sustained release injection which comprises agiogenesis inhibitor and anticarcinogen sustained release preparation of synergistic agent thereof. The sustained release injection comprises sustained release microspheres and menstruum; wherein, the sustained release microspheres comprise anticancer active principles and sustained release auxiliary material.The menstruum is a special menstruum that contains suspending agent. The anticancer active principles are agiogenesis inhibitor and/or synergistic agent of the agiogenesis inhibitor selected from hormone anticarcinogens and/or platinum compounds; the sustained release auxiliary material is one or the compositions of poly-dl-lactide and copolymer thereof, monomethyl polyethylene glycol and polylactictide copolymer, polyethylene glycol and polylactictide copolymer, terminal carboxyl group polylactic acid and glycolic acid copolymer, di-fatty acid and decanedioic acid copolymer, poly (erucic acid dipolymer decanedioic acid), poly (fumaric acid decanedioic acid), polifeprosan and copolymer of ethylene-vinyl acetate; the viscosity of the suspending agent is 80cp-3,000cp. The sustained release microspheres, which can also be made into sustained release implant to be injected or placed in or around tumor, with the release lasting as long as about 40 days, can be used solely or in combination with chemotherapeutics and/or with non-operative treatments, such as radiotherapy, etc.

Compounds of formula I as defined herein, or pharmaceutically acceptable salts, solvates or derivatives thereof, are potent inhibitors of angiogenesis and accordingly are of use in the treatment and prevention of various angiogenesis-related disorders such as cancer.

Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.