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People with diabetes can have an eye disease called diabetic retinopathy. This is when high blood sugar levels cause damage to blood vessels in the retina. These blood vessels can swell and leak.
Use of supermeres derived from human umbilical cord mesenchymal stem cells in preparation of drugs for treating diabetic retinal fibrosis
The application provides application of human umbilical cord mesenchymal stem cell-derived Supermeres in preparation of a medicine for treating diabetic retinal fibrosis, and belongs to the technical field of biological medicine; the application research finds that the human umbilical cord mesenchymal stem cell-derived Supermeres can significantly inhibit retinal cell fibrosis, reduce the expression of fibrosis marker proteins alpha-SMA, col-1a1 and Fibronectin, compared with human umbilical cord mesenchymal stem cell-derived EVs, can not only better inhibit the occurrence of fibrosis, but also more significantly inhibit cell apoptosis and promote cell proliferation, so that the technical effect of treating retinal fibrosis is achieved; the human umbilical cord mesenchymal stem cell-derived Supermeres have good application in preparation of the medicine for treating diabetic retinal fibrosis.
Owner:JIANGSU UNIV